Detailed information NTG1025876

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: AB3442_RS10180
• Genome accession: NZ_CP162453
• Coordinates: 2053924..2055552 (+)
• Length: 542 a.a.
• NCBI ID: WP_001186608.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain TUM20929
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	2052553..2070951	2053924..2055552	within	0
SCCmec	2052553..2062316	2053924..2055552	within	0

Gene organization within MGE regions

Location: 2052553..2070951

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3442_RS10175 (AB3442_10175)	ccrA	2052553..2053902 (+)	1350	WP_000815640.1	cassette chromosome recombinase CcrA	Machinery gene
AB3442_RS10180 (AB3442_10180)	ccrB	2053924..2055552 (+)	1629	WP_001186608.1	cassette chromosome recombinase CcrB	Machinery gene
AB3442_RS10185 (AB3442_10185)	-	2056074..2056424 (+)	351	WP_000849672.1	SAUGI family uracil-DNA glycosylase inhibitor	-
AB3442_RS10190 (AB3442_10190)	-	2056511..2056821 (+)	311	Protein_1968	DUF960 family protein	-
AB3442_RS10195 (AB3442_10195)	-	2056836..2057342 (+)	507	WP_001092189.1	DUF1643 domain-containing protein	-
AB3442_RS10200 (AB3442_10200)	-	2057394..2059001 (+)	1608	Protein_1970	IS1182 family transposase	-
AB3442_RS10205 (AB3442_10205)	-	2058992..2059252 (-)	261	WP_001549961.1	type I restriction enzyme endonuclease domain-containing protein	-
AB3442_RS10210 (AB3442_10210)	-	2059224..2060210 (-)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
AB3442_RS10215 (AB3442_10215)	mecA	2060307..2062316 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
AB3442_RS10220 (AB3442_10220)	-	2062362..2062790 (-)	429	WP_000872606.1	MaoC family dehydratase	-
AB3442_RS10225 (AB3442_10225)	-	2062887..2063630 (-)	744	WP_000958858.1	glycerophosphoryl diester phosphodiesterase	-
AB3442_RS10230 (AB3442_10230)	-	2064507..2064896 (-)	390	WP_020444595.1	hydroxymethylglutaryl-CoA synthase	-
AB3442_RS10235 (AB3442_10235)	-	2064932..2065606 (+)	675	WP_001106057.1	IS6-like element IS257 family transposase	-
AB3442_RS10240 (AB3442_10240)	aadD1	2065799..2066569 (+)	771	WP_001795128.1	aminoglycoside O-nucleotidyltransferase ANT(4')-Ia	-
AB3442_RS10245 (AB3442_10245)	bleO	2066786..2067190 (+)	405	WP_368410423.1	bleomycin binding protein	-
AB3442_RS10250 (AB3442_10250)	mobV	2067697..2068958 (+)	1262	Protein_1980	MobV family relaxase	-
AB3442_RS10255 (AB3442_10255)	-	2069203..2070186 (+)	984	Protein_1981	protein rep	-
AB3442_RS10260 (AB3442_10260)	-	2070277..2070951 (+)	675	WP_001106057.1	IS6-like element IS257 family transposase	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62654.83 Da
• Isoelectric Point: 9.7970

>NTDB_id=1025876 AB3442_RS10180 WP_001186608.1 2053924..2055552(+) (ccrB) [Staphylococcus aureus strain TUM20929]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=1025876 AB3442_RS10180 WP_001186608.1 2053924..2055552(+) (ccrB) [Staphylococcus aureus strain TUM20929]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACTCTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAACACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (180-280)

• Resolvase, N terminal domain (Resolvase) (11-156)

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	98.893	100	0.989