Detailed information NTG1025808

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB3450_RS06800
• Genome accession: NZ_CP162449
• Coordinates: 1376009..1377052 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20967
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1371009..1382052

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3450_RS06770 (AB3450_06770)	-	1371375..1371486 (+)	112	Protein_1316	hypothetical protein	-
AB3450_RS06775 (AB3450_06775)	-	1371515..1371928 (+)	414	WP_001837236.1	hypothetical protein	-
AB3450_RS06780 (AB3450_06780)	-	1372418..1373404 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
AB3450_RS06785 (AB3450_06785)	map	1373935..1374693 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB3450_RS06790 (AB3450_06790)	-	1374910..1375296 (+)	387	WP_001110179.1	hypothetical protein	-
AB3450_RS06795 (AB3450_06795)	liaF	1375311..1376012 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB3450_RS06800 (AB3450_06800)	vraS	1376009..1377052 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB3450_RS06805 (AB3450_06805)	vraR	1377042..1377671 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AB3450_RS06810 (AB3450_06810)	-	1377783..1378994 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
AB3450_RS06815 (AB3450_06815)	-	1379272..1379547 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
AB3450_RS06820 (AB3450_06820)	-	1379554..1380018 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AB3450_RS06825 (AB3450_06825)	-	1380165..1380365 (+)	201	WP_000180460.1	DUF1128 family protein	-
AB3450_RS06830 (AB3450_06830)	-	1380368..1381624 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1025808 AB3450_RS06800 WP_001017131.1 1376009..1377052(+) (vraS) [Staphylococcus aureus strain TUM20967]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1025808 AB3450_RS06800 WP_001017131.1 1376009..1377052(+) (vraS) [Staphylococcus aureus strain TUM20967]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1