Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | AB3446_RS10525 | Genome accession | NZ_CP162440 |
| Coordinates | 2093419..2094768 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain TUM22457 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2093419..2142951 | 2093419..2094768 | within | 0 |
Gene organization within MGE regions
Location: 2093419..2142951
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AB3446_RS10525 (AB3446_10525) | ccrA | 2093419..2094768 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| AB3446_RS10530 (AB3446_10530) | ccrB | 2094790..2096418 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| AB3446_RS10535 (AB3446_10535) | - | 2096936..2097286 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| AB3446_RS10540 (AB3446_10540) | - | 2097373..2097684 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| AB3446_RS10545 (AB3446_10545) | - | 2097702..2098208 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| AB3446_RS10550 (AB3446_10550) | - | 2098229..2098546 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| AB3446_RS10555 (AB3446_10555) | - | 2098665..2099750 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| AB3446_RS10560 (AB3446_10560) | - | 2099747..2101639 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| AB3446_RS10565 (AB3446_10565) | - | 2101646..2102023 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| AB3446_RS10570 (AB3446_10570) | - | 2102174..2102956 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| AB3446_RS10575 (AB3446_10575) | erm(A) | 2103082..2103813 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| AB3446_RS10580 (AB3446_10580) | - | 2103896..2103955 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| AB3446_RS10585 (AB3446_10585) | - | 2104347..2105009 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| AB3446_RS10590 (AB3446_10590) | - | 2105354..2105992 (-) | 639 | Protein_2051 | sulfite exporter TauE/SafE family protein | - |
| AB3446_RS10595 (AB3446_10595) | cstR | 2105992..2106252 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| AB3446_RS10600 (AB3446_10600) | - | 2106388..2107452 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| AB3446_RS10605 (AB3446_10605) | cstB | 2107485..2108819 (+) | 1335 | Protein_2054 | persulfide dioxygenase-sulfurtransferase CstB | - |
| AB3446_RS10610 (AB3446_10610) | - | 2108933..2110063 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| AB3446_RS10615 (AB3446_10615) | psm-mec | 2110397..2110465 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| AB3446_RS10620 (AB3446_10620) | mecI | 2110550..2110921 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| AB3446_RS10625 (AB3446_10625) | mecR1 | 2110921..2112678 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| AB3446_RS10630 (AB3446_10630) | mecA | 2112775..2114784 (+) | 2010 | WP_218089213.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| AB3446_RS10635 (AB3446_10635) | - | 2114830..2115258 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| AB3446_RS10640 (AB3446_10640) | - | 2115355..2116098 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| AB3446_RS10645 (AB3446_10645) | - | 2116815..2117204 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| AB3446_RS10650 (AB3446_10650) | - | 2117240..2117914 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| AB3446_RS10655 (AB3446_10655) | aadD1 | 2118107..2118877 (+) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| AB3446_RS10660 (AB3446_10660) | bleO | 2119094..2119498 (+) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| AB3446_RS10665 (AB3446_10665) | mobV | 2120005..2121258 (+) | 1254 | WP_368409905.1 | MobV family relaxase | - |
| AB3446_RS10670 (AB3446_10670) | - | 2121503..2122486 (+) | 984 | Protein_2067 | protein rep | - |
| AB3446_RS10675 (AB3446_10675) | - | 2122577..2123251 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| AB3446_RS10680 (AB3446_10680) | - | 2123283..2123522 (-) | 240 | WP_001282728.1 | hypothetical protein | - |
| AB3446_RS10685 (AB3446_10685) | - | 2123937..2125193 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| AB3446_RS10690 (AB3446_10690) | - | 2125668..2125835 (-) | 168 | WP_000669688.1 | hypothetical protein | - |
| AB3446_RS10695 (AB3446_10695) | - | 2126485..2126697 (+) | 213 | WP_001257909.1 | DUF1958 domain-containing protein | - |
| AB3446_RS10700 (AB3446_10700) | - | 2126786..2128204 (+) | 1419 | WP_032605060.1 | aspartate aminotransferase family protein | - |
| AB3446_RS10705 (AB3446_10705) | - | 2128272..2128454 (-) | 183 | Protein_2074 | MFS transporter | - |
| AB3446_RS10710 (AB3446_10710) | - | 2128664..2130412 (-) | 1749 | WP_000585108.1 | UvrD-helicase domain-containing protein | - |
| AB3446_RS10715 (AB3446_10715) | - | 2130414..2132510 (-) | 2097 | WP_223200550.1 | ATP-dependent endonuclease | - |
| AB3446_RS10720 (AB3446_10720) | - | 2132919..2134433 (+) | 1515 | WP_000190901.1 | class I SAM-dependent DNA methyltransferase | - |
| AB3446_RS10725 (AB3446_10725) | - | 2134423..2135724 (+) | 1302 | WP_000456234.1 | restriction endonuclease subunit S | - |
| AB3446_RS10730 (AB3446_10730) | - | 2135708..2138827 (+) | 3120 | WP_368409904.1 | type I restriction endonuclease subunit R | - |
| AB3446_RS10735 (AB3446_10735) | - | 2138905..2139471 (-) | 567 | WP_002437520.1 | hypothetical protein | - |
| AB3446_RS10740 (AB3446_10740) | - | 2139686..2139907 (-) | 222 | WP_002437519.1 | hypothetical protein | - |
| AB3446_RS10745 (AB3446_10745) | - | 2139921..2140424 (-) | 504 | WP_002437518.1 | DUF1643 domain-containing protein | - |
| AB3446_RS10750 (AB3446_10750) | - | 2140440..2140751 (-) | 312 | WP_032604337.1 | DUF960 family protein | - |
| AB3446_RS10755 (AB3446_10755) | - | 2140845..2141183 (-) | 339 | WP_032604336.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| AB3446_RS10760 (AB3446_10760) | - | 2141272..2142951 (-) | 1680 | WP_368409903.1 | recombinase family protein | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=1025613 AB3446_RS10525 WP_000815646.1 2093419..2094768(+) (ccrA) [Staphylococcus aureus strain TUM22457]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=1025613 AB3446_RS10525 WP_000815646.1 2093419..2094768(+) (ccrA) [Staphylococcus aureus strain TUM22457]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |