Detailed information NTG1025605

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB3446_RS06050
• Genome accession: NZ_CP162440
• Coordinates: 1191074..1192117 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22457
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1186074..1197117

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3446_RS06020 (AB3446_06020)	-	1186495..1187751 (-)	1257	WP_001795108.1	aminopeptidase	-
AB3446_RS06025 (AB3446_06025)	-	1187754..1187954 (-)	201	WP_000180460.1	DUF1128 family protein	-
AB3446_RS06030 (AB3446_06030)	-	1188101..1188565 (+)	465	WP_042109418.1	low molecular weight protein-tyrosine-phosphatase	-
AB3446_RS06035 (AB3446_06035)	-	1188572..1188847 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AB3446_RS06040 (AB3446_06040)	-	1189125..1190342 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AB3446_RS06045 (AB3446_06045)	vraR	1190455..1191084 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AB3446_RS06050 (AB3446_06050)	vraS	1191074..1192117 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB3446_RS06055 (AB3446_06055)	liaF	1192114..1192815 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB3446_RS06060 (AB3446_06060)	-	1192830..1193216 (-)	387	WP_001110179.1	hypothetical protein	-
AB3446_RS06065 (AB3446_06065)	map	1193433..1194191 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB3446_RS06070 (AB3446_06070)	-	1194722..1195708 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
AB3446_RS06075 (AB3446_06075)	-	1196139..1196552 (-)	414	WP_001557448.1	hypothetical protein	-
AB3446_RS06080 (AB3446_06080)	-	1196581..1196691 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1025605 AB3446_RS06050 WP_001017131.1 1191074..1192117(-) (vraS) [Staphylococcus aureus strain TUM22457]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1025605 AB3446_RS06050 WP_001017131.1 1191074..1192117(-) (vraS) [Staphylococcus aureus strain TUM22457]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1