Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | AB3435_RS03625 | Genome accession | NZ_CP162438 |
| Coordinates | 716345..717694 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain TUM22458 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 668162..717694 | 716345..717694 | within | 0 |
Gene organization within MGE regions
Location: 668162..717694
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AB3435_RS03385 (AB3435_03385) | - | 668162..669841 (+) | 1680 | WP_368409903.1 | recombinase family protein | - |
| AB3435_RS03390 (AB3435_03390) | - | 669930..670268 (+) | 339 | WP_032604336.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| AB3435_RS03395 (AB3435_03395) | - | 670362..670673 (+) | 312 | WP_032604337.1 | DUF960 family protein | - |
| AB3435_RS03400 (AB3435_03400) | - | 670689..671192 (+) | 504 | WP_002437518.1 | DUF1643 domain-containing protein | - |
| AB3435_RS03405 (AB3435_03405) | - | 671206..671427 (+) | 222 | WP_002437519.1 | hypothetical protein | - |
| AB3435_RS03410 (AB3435_03410) | - | 671642..672208 (+) | 567 | WP_002437520.1 | hypothetical protein | - |
| AB3435_RS03415 (AB3435_03415) | - | 672286..675405 (-) | 3120 | WP_368409904.1 | type I restriction endonuclease subunit R | - |
| AB3435_RS03420 (AB3435_03420) | - | 675389..676690 (-) | 1302 | WP_000456234.1 | restriction endonuclease subunit S | - |
| AB3435_RS03425 (AB3435_03425) | - | 676680..678194 (-) | 1515 | WP_000190901.1 | class I SAM-dependent DNA methyltransferase | - |
| AB3435_RS03430 (AB3435_03430) | - | 678603..680699 (+) | 2097 | WP_223200550.1 | ATP-dependent endonuclease | - |
| AB3435_RS03435 (AB3435_03435) | - | 680701..682449 (+) | 1749 | WP_000585108.1 | UvrD-helicase domain-containing protein | - |
| AB3435_RS03440 (AB3435_03440) | - | 682659..682841 (+) | 183 | Protein_682 | MFS transporter | - |
| AB3435_RS03445 (AB3435_03445) | - | 682909..684327 (-) | 1419 | WP_032605060.1 | aspartate aminotransferase family protein | - |
| AB3435_RS03450 (AB3435_03450) | - | 684416..684628 (-) | 213 | WP_001257909.1 | DUF1958 domain-containing protein | - |
| AB3435_RS03455 (AB3435_03455) | - | 685278..685445 (+) | 168 | WP_000669688.1 | hypothetical protein | - |
| AB3435_RS03460 (AB3435_03460) | - | 685920..687176 (+) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| AB3435_RS03465 (AB3435_03465) | - | 687591..687830 (+) | 240 | WP_001282728.1 | hypothetical protein | - |
| AB3435_RS03470 (AB3435_03470) | - | 687862..688536 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| AB3435_RS03475 (AB3435_03475) | - | 688627..689610 (-) | 984 | Protein_689 | protein rep | - |
| AB3435_RS03480 (AB3435_03480) | mobV | 689855..691108 (-) | 1254 | WP_368409905.1 | MobV family relaxase | - |
| AB3435_RS03485 (AB3435_03485) | bleO | 691615..692019 (-) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| AB3435_RS03490 (AB3435_03490) | aadD1 | 692236..693006 (-) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| AB3435_RS03495 (AB3435_03495) | - | 693199..693873 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| AB3435_RS03500 (AB3435_03500) | - | 693957..694298 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| AB3435_RS03505 (AB3435_03505) | - | 695015..695758 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| AB3435_RS03510 (AB3435_03510) | - | 695855..696283 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| AB3435_RS03515 (AB3435_03515) | mecA | 696329..698338 (-) | 2010 | WP_218089213.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| AB3435_RS03520 (AB3435_03520) | mecR1 | 698435..700192 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| AB3435_RS03525 (AB3435_03525) | mecI | 700192..700563 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| AB3435_RS03530 (AB3435_03530) | psm-mec | 700648..700716 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| AB3435_RS03535 (AB3435_03535) | - | 701050..702180 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| AB3435_RS03540 (AB3435_03540) | cstB | 702294..703628 (-) | 1335 | Protein_702 | persulfide dioxygenase-sulfurtransferase CstB | - |
| AB3435_RS03545 (AB3435_03545) | - | 703661..704725 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| AB3435_RS03550 (AB3435_03550) | cstR | 704861..705121 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| AB3435_RS03555 (AB3435_03555) | - | 705121..705759 (+) | 639 | Protein_705 | sulfite exporter TauE/SafE family protein | - |
| AB3435_RS03560 (AB3435_03560) | - | 705810..705872 (-) | 63 | Protein_706 | DNA repair protein RadC | - |
| AB3435_RS03565 (AB3435_03565) | - | 706104..706766 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| AB3435_RS03570 (AB3435_03570) | - | 707158..707217 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| AB3435_RS03575 (AB3435_03575) | erm(A) | 707300..708031 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| AB3435_RS03580 (AB3435_03580) | - | 708157..708939 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| AB3435_RS03585 (AB3435_03585) | - | 709090..709467 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| AB3435_RS03590 (AB3435_03590) | - | 709474..711366 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| AB3435_RS03595 (AB3435_03595) | - | 711363..712448 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| AB3435_RS03600 (AB3435_03600) | - | 712567..712884 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| AB3435_RS03605 (AB3435_03605) | - | 712905..713411 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| AB3435_RS03610 (AB3435_03610) | - | 713429..713740 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| AB3435_RS03615 (AB3435_03615) | - | 713827..714177 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| AB3435_RS03620 (AB3435_03620) | ccrB | 714695..716323 (-) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| AB3435_RS03625 (AB3435_03625) | ccrA | 716345..717694 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=1025539 AB3435_RS03625 WP_000815646.1 716345..717694(-) (ccrA) [Staphylococcus aureus strain TUM22458]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=1025539 AB3435_RS03625 WP_000815646.1 716345..717694(-) (ccrA) [Staphylococcus aureus strain TUM22458]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |