Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   AB3424_RS12215 Genome accession   NZ_CP162436
Coordinates   2432059..2433408 (-) Length   449 a.a.
NCBI ID   WP_117219606.1    Uniprot ID   -
Organism   Staphylococcus aureus strain TUM22699     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2423704..2433408 2432059..2433408 within 0


Gene organization within MGE regions


Location: 2423704..2433408
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB3424_RS12175 (AB3424_12175) mecA 2423704..2425713 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  AB3424_RS12180 (AB3424_12180) - 2425810..2426796 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  AB3424_RS12185 (AB3424_12185) - 2426768..2427028 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  AB3424_RS12190 (AB3424_12190) - 2427019..2428626 (-) 1608 Protein_2369 IS1182 family transposase -
  AB3424_RS12195 (AB3424_12195) - 2428678..2429184 (-) 507 WP_001092195.1 DUF1643 domain-containing protein -
  AB3424_RS12200 (AB3424_12200) - 2429199..2429510 (-) 312 WP_001024803.1 DUF960 family protein -
  AB3424_RS12205 (AB3424_12205) - 2429597..2429947 (-) 351 WP_000859157.1 SAUGI family uracil-DNA glycosylase inhibitor -
  AB3424_RS12210 (AB3424_12210) - 2430413..2432037 (-) 1625 Protein_2373 recombinase family protein -
  AB3424_RS12215 (AB3424_12215) ccrA 2432059..2433408 (-) 1350 WP_117219606.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52581.35 Da        Isoelectric Point: 9.9370

>NTDB_id=1025490 AB3424_RS12215 WP_117219606.1 2432059..2433408(-) (ccrA) [Staphylococcus aureus strain TUM22699]
MKQAIGYLRQSTTKQQSLAAQKQTIEALAKKHNIQYITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKMITTHAPFGYHYH
NGTFTIDTVKAPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKPVKRKPSENQLKQKIKCPYCDSTLTNMTIRKKHHTLRYYVCPQNMNASRFVCEFKGINAQELETSVLAT
CQDFFQNQQLYSKINHTIQQRLKRQRDIETKTTLNHEQLIEKLAQDKIDAETFREQTQSLRQQSKPISSISTYQIRKAFQ
NIIQQRFTLNMLYPYIDEINNSKNKSLAGIYFKNEPLNIVKQTMELSIV

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1025490 AB3424_RS12215 WP_117219606.1 2432059..2433408(-) (ccrA) [Staphylococcus aureus strain TUM22699]
ATGAAACAAGCAATAGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCGAGGC
ATTAGCCAAAAAACATAATATTCAATACATTACCTTTTATAGCGATAAGCAATCAGGACGCACTGATAAGCGGAACGGTT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATGTGATGTATTATGTTGTTACAGATTAAACCGACTTCATCGCAAT
CTTAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTATTTTGA
TATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAAATGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAAGCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAAATTCATTAATCGTAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACCAGTAAAACGTAAGCCGTCAGAAAACCAACTCAAACAAAAAATCAA
ATGTCCTTATTGTGATTCAACACTAACTAATATGACCATTAGAAAAAAGCACCATACATTACGTTATTATGTTTGTCCTC
AAAATATGAATGCATCTCGTTTTGTCTGTGAATTCAAAGGGATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TATAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGACAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAGCAATCAAAACCTATATCATCAATCAGTACGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATAATTCTAAAAATAAAAGCCT
CGCTGGCATCTATTTCAAAAATGAACCACTGAATATTGTAAAGCAGACTATGGAATTATCAATTGTATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(170-249)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

99.777

100

0.998
  ccrA Staphylococcus aureus N315

74.61

100

0.746

Multiple sequence alignment