Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   AB3426_RS09835 Genome accession   NZ_CP162433
Coordinates   2002001..2003362 (-) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus aureus strain TUM22701     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 1940309..2011690 2002001..2003362 within 0


Gene organization within MGE regions


Location: 1940309..2011690
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB3426_RS09525 (AB3426_09525) ccrA 1940309..1941658 (+) 1350 WP_000815646.1 cassette chromosome recombinase CcrA Machinery gene
  AB3426_RS09530 (AB3426_09530) ccrB 1941680..1943308 (+) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  AB3426_RS09535 (AB3426_09535) - 1943826..1944176 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  AB3426_RS09540 (AB3426_09540) - 1944263..1944574 (+) 312 WP_000700853.1 DUF960 family protein -
  AB3426_RS09545 (AB3426_09545) - 1944592..1945098 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  AB3426_RS09550 (AB3426_09550) - 1945119..1945436 (+) 318 WP_000659050.1 JAB domain-containing protein -
  AB3426_RS09555 (AB3426_09555) - 1945555..1946640 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  AB3426_RS09560 (AB3426_09560) - 1946637..1948529 (+) 1893 WP_001557544.1 site-specific integrase -
  AB3426_RS09565 (AB3426_09565) - 1948536..1948913 (+) 378 WP_000361059.1 DUF6262 family protein -
  AB3426_RS09570 (AB3426_09570) - 1949064..1949846 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  AB3426_RS09575 (AB3426_09575) erm(A) 1949972..1950703 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  AB3426_RS09580 (AB3426_09580) - 1950786..1950845 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  AB3426_RS09585 (AB3426_09585) - 1951237..1951899 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  AB3426_RS09590 (AB3426_09590) - 1952244..1952882 (-) 639 Protein_1893 sulfite exporter TauE/SafE family protein -
  AB3426_RS09595 (AB3426_09595) cstR 1952882..1953142 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  AB3426_RS09600 (AB3426_09600) - 1953278..1954342 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  AB3426_RS09605 (AB3426_09605) cstB 1954375..1955709 (+) 1335 Protein_1896 persulfide dioxygenase-sulfurtransferase CstB -
  AB3426_RS09610 (AB3426_09610) - 1955823..1956932 (-) 1110 WP_000943131.1 ROK family transcriptional regulator -
  AB3426_RS09615 (AB3426_09615) psm-mec 1957287..1957355 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  AB3426_RS09620 (AB3426_09620) mecI 1957440..1957811 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  AB3426_RS09625 (AB3426_09625) mecR1 1957811..1959568 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  AB3426_RS09630 (AB3426_09630) mecA 1959665..1961674 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  AB3426_RS09635 (AB3426_09635) - 1961720..1962148 (-) 429 WP_000872606.1 MaoC family dehydratase -
  AB3426_RS09640 (AB3426_09640) - 1962245..1962988 (-) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  AB3426_RS09645 (AB3426_09645) - 1963825..1964214 (-) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  AB3426_RS09650 (AB3426_09650) - 1964250..1964924 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  AB3426_RS09655 (AB3426_09655) hutH 1965044..1966558 (+) 1515 WP_000177465.1 histidine ammonia-lyase -
  AB3426_RS09660 (AB3426_09660) serS 1966937..1968223 (+) 1287 WP_000884332.1 serine--tRNA ligase -
  AB3426_RS09665 (AB3426_09665) - 1968874..1969569 (+) 696 WP_000190726.1 AzlC family ABC transporter permease -
  AB3426_RS09670 (AB3426_09670) - 1969566..1969895 (+) 330 WP_000628051.1 AzlD domain-containing protein -
  AB3426_RS09675 (AB3426_09675) - 1970258..1971226 (+) 969 WP_000186490.1 alpha/beta fold hydrolase family protein -
  AB3426_RS09680 (AB3426_09680) - 1971519..1972457 (+) 939 WP_341262116.1 YybS family protein -
  AB3426_RS09685 (AB3426_09685) gdpP 1972472..1974439 (+) 1968 WP_001081640.1 cyclic-di-AMP phosphodiesterase GdpP -
  AB3426_RS09690 (AB3426_09690) rplI 1974436..1974882 (+) 447 WP_000864305.1 50S ribosomal protein L9 -
  AB3426_RS09695 (AB3426_09695) dnaB 1974914..1976314 (+) 1401 WP_000375647.1 replicative DNA helicase -
  AB3426_RS09700 (AB3426_09700) - 1976592..1977875 (+) 1284 WP_000095328.1 adenylosuccinate synthase -
  AB3426_RS09715 (AB3426_09715) yycF 1979078..1979779 (+) 702 WP_000101976.1 response regulator YycF -
  AB3426_RS09720 (AB3426_09720) walK 1979792..1981618 (+) 1827 WP_000871607.1 cell wall metabolism sensor histidine kinase WalK -
  AB3426_RS09725 (AB3426_09725) yycH 1981611..1982945 (+) 1335 WP_001060140.1 two-component system activity regulator YycH -
  AB3426_RS09730 (AB3426_09730) - 1982946..1983734 (+) 789 WP_001104165.1 two-component system regulatory protein YycI -
  AB3426_RS09735 (AB3426_09735) - 1984123..1984923 (+) 801 WP_000088649.1 MBL fold metallo-hydrolase -
  AB3426_RS09740 (AB3426_09740) adsA 1985150..1987468 (+) 2319 WP_341262117.1 LPXTG-anchored adenosine synthase AdsA -
  AB3426_RS09745 (AB3426_09745) rlmH 1987836..1988315 (+) 480 WP_000704775.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AB3426_RS09750 (AB3426_09750) - 1988416..1988559 (+) 144 WP_001631028.1 restriction endonuclease subunit R -
  AB3426_RS09755 (AB3426_09755) - 1988552..1989754 (+) 1203 WP_001631029.1 restriction endonuclease subunit S -
  AB3426_RS09760 (AB3426_09760) - 1989799..1990015 (-) 217 Protein_1925 IS5/IS1182 family transposase -
  AB3426_RS09765 (AB3426_09765) - 1990077..1990574 (-) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  AB3426_RS09770 (AB3426_09770) - 1991246..1991656 (-) 411 WP_001631031.1 DUF2871 domain-containing protein -
  AB3426_RS09775 (AB3426_09775) - 1991819..1992039 (-) 221 Protein_1928 hypothetical protein -
  AB3426_RS09780 (AB3426_09780) - 1992054..1992557 (-) 504 WP_001631032.1 DUF1643 domain-containing protein -
  AB3426_RS09785 (AB3426_09785) - 1992573..1992812 (-) 240 Protein_1930 DUF960 family protein -
  AB3426_RS09790 (AB3426_09790) blaZ 1993113..1993959 (-) 847 Protein_1931 penicillin-hydrolyzing class A beta-lactamase BlaZ -
  AB3426_RS09795 (AB3426_09795) blaR1 1994066..1995823 (+) 1758 WP_001096381.1 beta-lactam sensor/signal transducer BlaR1 -
  AB3426_RS09800 (AB3426_09800) blaI 1995813..1996193 (+) 381 WP_000182645.1 penicillinase repressor BlaI -
  AB3426_RS09805 (AB3426_09805) - 1996457..1997050 (+) 594 WP_000690638.1 recombinase family protein -
  AB3426_RS09810 (AB3426_09810) - 1997022..1998464 (+) 1443 WP_002451367.1 Mu transposase C-terminal domain-containing protein -
  AB3426_RS09815 (AB3426_09815) - 1998457..1999272 (+) 816 WP_000164963.1 AAA family ATPase -
  AB3426_RS09820 (AB3426_09820) - 1999358..1999438 (-) 81 Protein_1937 DUF960 family protein -
  AB3426_RS09825 (AB3426_09825) - 1999525..1999875 (-) 351 WP_001631034.1 SAUGI family uracil-DNA glycosylase inhibitor -
  AB3426_RS09830 (AB3426_09830) ccrB 2000376..2002004 (-) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene
  AB3426_RS09835 (AB3426_09835) ccrA 2002001..2003362 (-) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  AB3426_RS09840 (AB3426_09840) - 2003549..2004178 (-) 630 Protein_1941 hypothetical protein -
  AB3426_RS09845 (AB3426_09845) - 2004187..2004525 (+) 339 Protein_1942 recombinase family protein -
  AB3426_RS09850 (AB3426_09850) - 2004637..2004996 (-) 360 WP_001631039.1 hypothetical protein -
  AB3426_RS09855 (AB3426_09855) - 2005203..2005529 (+) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  AB3426_RS09860 (AB3426_09860) - 2005859..2006182 (+) 324 Protein_1945 heavy metal translocating P-type ATPase -
  AB3426_RS09865 (AB3426_09865) - 2006239..2006913 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  AB3426_RS09870 (AB3426_09870) - 2006945..2007184 (-) 240 WP_001282728.1 hypothetical protein -
  AB3426_RS09875 (AB3426_09875) - 2007599..2008855 (-) 1257 WP_000566670.1 DUF3578 domain-containing protein -
  AB3426_RS09880 (AB3426_09880) - 2010081..2011688 (-) 1608 Protein_1949 heavy metal translocating P-type ATPase -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=1025437 AB3426_RS09835 WP_001631036.1 2002001..2003362(-) (ccrA) [Staphylococcus aureus strain TUM22701]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=1025437 AB3426_RS09835 WP_001631036.1 2002001..2003362(-) (ccrA) [Staphylococcus aureus strain TUM22701]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494

Multiple sequence alignment