Detailed information NTG1025230

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB3436_RS01440
• Genome accession: NZ_CP162425
• Coordinates: 272798..273841 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22721
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 267798..278841

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3436_RS01410 (AB3436_01405)	-	268216..269472 (-)	1257	WP_108932452.1	aminopeptidase	-
AB3436_RS01415 (AB3436_01410)	-	269475..269675 (-)	201	WP_000180461.1	DUF1128 family protein	-
AB3436_RS01420 (AB3436_01415)	-	269822..270286 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AB3436_RS01425 (AB3436_01420)	-	270293..270568 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AB3436_RS01430 (AB3436_01425)	-	270846..272063 (+)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
AB3436_RS01435 (AB3436_01430)	vraR	272179..272808 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
AB3436_RS01440 (AB3436_01435)	vraS	272798..273841 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB3436_RS01445 (AB3436_01440)	liaF	273838..274539 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB3436_RS01450 (AB3436_01445)	-	274554..274940 (-)	387	WP_001110179.1	hypothetical protein	-
AB3436_RS01455 (AB3436_01450)	map	275157..275915 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB3436_RS01460 (AB3436_01455)	-	276502..277488 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
AB3436_RS01465 (AB3436_01460)	-	277919..278332 (-)	414	WP_001549145.1	hypothetical protein	-
AB3436_RS01470 (AB3436_01465)	-	278361..278471 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1025230 AB3436_RS01440 WP_001017131.1 272798..273841(-) (vraS) [Staphylococcus aureus strain TUM22721]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1025230 AB3436_RS01440 WP_001017131.1 272798..273841(-) (vraS) [Staphylococcus aureus strain TUM22721]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1