Detailed information NTG1025185

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB3445_RS00915
• Genome accession: NZ_CP162422
• Coordinates: 155133..156176 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22723
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 150133..161176

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3445_RS00885 (AB3445_00885)	-	150561..150671 (+)	111	WP_001790257.1	hypothetical protein	-
AB3445_RS00890 (AB3445_00890)	-	150700..151113 (+)	414	WP_001549145.1	hypothetical protein	-
AB3445_RS00895 (AB3445_00895)	-	151544..152530 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
AB3445_RS00900 (AB3445_00900)	map	153058..153816 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB3445_RS00905 (AB3445_00905)	-	154033..154420 (+)	388	Protein_177	hypothetical protein	-
AB3445_RS00910 (AB3445_00910)	liaF	154435..155136 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB3445_RS00915 (AB3445_00915)	vraS	155133..156176 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB3445_RS00920 (AB3445_00920)	vraR	156166..156795 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
AB3445_RS00925 (AB3445_00925)	-	156911..158128 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AB3445_RS00930 (AB3445_00930)	-	158406..158681 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
AB3445_RS00935 (AB3445_00935)	-	158688..159152 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AB3445_RS00940 (AB3445_00940)	-	159299..159499 (+)	201	WP_000180461.1	DUF1128 family protein	-
AB3445_RS00945 (AB3445_00945)	-	159502..160758 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1025185 AB3445_RS00915 WP_001017131.1 155133..156176(+) (vraS) [Staphylococcus aureus strain TUM22723]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1025185 AB3445_RS00915 WP_001017131.1 155133..156176(+) (vraS) [Staphylococcus aureus strain TUM22723]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1