Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DQN28_RS08450 Genome accession   NZ_LS483430
Coordinates   1676403..1678385 (-) Length   660 a.a.
NCBI ID   WP_111686421.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12044     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1671403..1683385
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN28_RS08425 (NCTC12044_01669) recA 1671439..1672575 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  DQN28_RS08430 (NCTC12044_01670) cinA 1672664..1673935 (-) 1272 WP_002992182.1 competence/damage-inducible protein A Machinery gene
  DQN28_RS08435 (NCTC12044_01671) - 1674004..1674564 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  DQN28_RS08440 (NCTC12044_01672) ruvA 1674574..1675170 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA Machinery gene
  DQN28_RS08445 (NCTC12044_01673) - 1675172..1676392 (-) 1221 WP_002992187.1 MDR family MFS transporter -
  DQN28_RS08450 (NCTC12044_01674) hexB 1676403..1678385 (-) 1983 WP_111686421.1 DNA mismatch repair endonuclease MutL Machinery gene
  DQN28_RS08455 (NCTC12044_01675) - 1678480..1679631 (-) 1152 WP_172453924.1 tyrosine-type recombinase/integrase -
  DQN28_RS09220 - 1679880..1680023 (+) 144 WP_011185066.1 putative holin-like toxin -
  DQN28_RS08465 (NCTC12044_01677) - 1680906..1681586 (-) 681 WP_011185067.1 helix-turn-helix domain-containing protein -
  DQN28_RS08470 (NCTC12044_01678) - 1681750..1681947 (+) 198 WP_011185068.1 helix-turn-helix domain-containing protein -
  DQN28_RS08475 (NCTC12044_01679) - 1681961..1682569 (+) 609 WP_111686422.1 Bro-N domain-containing protein -
  DQN28_RS08480 (NCTC12044_01680) - 1682590..1682997 (+) 408 WP_002992501.1 hypothetical protein -
  DQN28_RS09225 (NCTC12044_01681) - 1683010..1683132 (+) 123 WP_011285272.1 hypothetical protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74450.08 Da        Isoelectric Point: 5.7605

>NTDB_id=1024500 DQN28_RS08450 WP_111686421.1 1676403..1678385(-) (hexB) [Streptococcus pyogenes strain NCTC12044]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKIMIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYFGTVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEEQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=1024500 DQN28_RS08450 WP_111686421.1 1676403..1678385(-) (hexB) [Streptococcus pyogenes strain NCTC12044]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCATGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTATATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAGTTGATGGCTTTAATTAGTACG
GCGATTTCTGAAAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTTCGGCACTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGAGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGTGAGGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(462-604)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-117)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.717

100

0.674

Multiple sequence alignment