Detailed information NTG1023964

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: DQN54_RS10360
• Genome accession: NZ_LS483417
• Coordinates: 1911635..1914169 (-)
• Length: 844 a.a.
• NCBI ID: WP_000963680.1
• Uniprot ID: A4L7L6
• Organism: Streptococcus pneumoniae strain NCTC11902
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1906635..1919169

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN54_RS10345 (NCTC11902_01987)	patB	1907237..1909003 (-)	1767	WP_000859850.1	multidrug efflux ABC transporter subunit PatB	-
DQN54_RS11895	-	1909195..1909644 (+)	450	Protein_1912	transposase	-
DQN54_RS10355 (NCTC11902_01989)	patA	1909794..1911488 (-)	1695	WP_000908148.1	multidrug efflux ABC transporter subunit PatA	-
DQN54_RS10360 (NCTC11902_01990)	hexA	1911635..1914169 (-)	2535	WP_000963680.1	DNA mismatch repair protein MutS	Machinery gene
DQN54_RS10365 (NCTC11902_01991)	argR	1914220..1914666 (-)	447	WP_001231468.1	arginine repressor	-
DQN54_RS10370 (NCTC11902_01992)	argS	1914802..1916493 (+)	1692	WP_001092701.1	arginine--tRNA ligase	-
DQN54_RS10375 (NCTC11902_01993)	-	1916808..1917366 (-)	559	Protein_1917	transposase	-
DQN54_RS10380 (NCTC11902_01994)	-	1917352..1917837 (+)	486	WP_001828807.1	cupin domain-containing protein	-
DQN54_RS10385 (NCTC11902_01995)	-	1917921..1918628 (+)	708	WP_000166475.1	response regulator transcription factor	-

Sequence

Protein

• Length: 844 a.a.
• Molecular weight: 94848.36 Da
• Isoelectric Point: 4.9494

>NTDB_id=1023964 DQN54_RS10360 WP_000963680.1 1911635..1914169(-) (hexA) [Streptococcus pneumoniae strain NCTC11902]
MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKP
VIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELESLISAAIAP
EAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKA
TLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFG
DDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLVTGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQTSA
VTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL

Nucleotide

• Length: 2535 bp

>NTDB_id=1023964 DQN54_RS10360 WP_000963680.1 1911635..1914169(-) (hexA) [Streptococcus pneumoniae strain NCTC11902]
ATGGCGATAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAAAAGCAATATCCAGATGCTTTTTTGCTCTT
TCGGATGGGTGATTTTTATGAATTATTTTATGAGGATGCGGTCAATGCTGCGCAGATTCTGGAAATTTCCTTAACGAGTC
GCAACAAGAATGCCGACAATCCGATCCCTATGGCGGGTGTTCCCTATCATTCTGCCCAACAGTATATCGATGTCTTGATT
GAGCAGGGTTATAAGGTGGCTATCGCAGAGCAGATGGAAGATCCTAAACAAGCAGTTGGGGTTGTTAAACGAGAGGTTGT
TCAGGTCATTACGCCAGGGACAGTGGTCGATAGCAGTAAGCCGGACAGTCAGAATAATTTTTTGGTTTCCATAGACCGCG
AAGGCAATCAATTTGGCCTAGCTTATATGGATTTGGTGACGGGTGACTTTTATGTGACAGGTCTTTTGGATTTCACGCTG
GTTTGTGGGGAAATCCGTAACCTCAAGGCTCGAGAAGTGGTGTTGGGTTATGACTTGTCTGAGGAAGAAGAACAAATCCT
CAGCCGCCAGATGAATCTGGTACTCTCTTATGAAAAAGAAAGCTTTGAAGACCTTCATTTATTGGATTTGCGATTGGCAA
CGGTGGAGCAAACGGCATCTAGTAAGCTGCTCCAGTATGTTCATCGGACTCAGATGAGGGAATTGAACCACCTCAAACCT
GTTATCCGCTACGAAATTAAGGATTTCTTGCAGATGGATTATGCGACCAAGGCTAGTCTGGATTTGGTTGAGAATGCTCG
CTCAGGTAAGAAACAAGGCAGTCTTTTCTGGCTTTTGGATGAAACCAAAACGGCTATGGGGATGCGTCTCTTGCGTTCTT
GGATTCATCGCCCCTTGATTGATAAGGAACGAATCGTCCAACGTCAAGAAGTAGTGCAGGTCTTTCTCGACCATTTCTTT
GAGCGTAGTGACTTGACAGACAGTCTCAAGGGTGTTTATGACATTGAGCGCTTGGCTAGTCGTGTTTCTTTTGGCAAAAC
CAATCCAAAGGATCTCTTGCAGTTGGCGACTACCTTGTCTAGTGTGCCACGGATTCGTGCGATTTTAGAAGGGATGGAGC
AACCTACTCTAGCCTATCTCATCGCACAACTGGATGCAATCCCTGAGTTGGAGAGTTTGATTAGCGCAGCGATTGCTCCT
GAAGCTCCTCATGTGATTACAGATGGGGGAATTATCCGAACTGGATTTGATGAGACTTTAGACAAGTATCGTTGCGTTCT
CAGAGAAGGGACTAGCTGGATTGCTGAGATTGAGGCTAAGGAGCGAGAAAACTCTGGTATCAGCACGCTCAAGATTGACT
ACAATAAAAAGGATGGCTACTATTTTCATGTGACCAATTCGCAACTAGGAAATGTGCCAGCCCACTTTTTCCGCAAGGCG
ACGCTGAAAAACTCAGAACGCTTTGGAACCGAAGAATTAGCCCGTATCGAGGGAGATATGCTTGAGGCGCGTGAGAAGTC
AGCCAACCTCGAATACGAAATATTTATGCGCATTCGTGAAGAGGTCGGCAAGTACATCCAGCGTTTACAAGCTCTAGCCC
AAGGAATTGCGACGGTTGATGTCTTACAGAGTCTGGCGGTTGTGGCTGAAACCCAGCATTTGATTCGACCTGAGTTTGGT
GACGATTCACAAATTGATATCCGGAAAGGGCGCCATGCTGTCGTTGAAAAGGTTATGGGGGCTCAGACCTATATTCCAAA
TACGATTCAGATGGCAGAAGATACCAGTATTCAACTGGTTACAGGGCCAAACATGAGTGGGAAGTCTACCTATATGCGTC
AGTTAGCCATGACGGCGGTTATGGCCCAGCTGGGTTCCTATGTTCCTGCTGAAAGCGCCCATTTACCGATTTTTGATGCG
ATTTTTACCCGTATCGGAGCAGCAGATGACTTGGTTTCGGGTCAGTCAACCTTTATGGTGGAGATGATGGAGGCCAATAA
TGCCATTTCGCATGCGACCAAGAACTCTCTCATTCTCTTTGATGAATTGGGACGTGGAACTGCAACTTATGACGGAATGG
CTCTTGCTCAGTCCATCATCGAATATATCCATGAGCACATCGGAGCTAAGACCCTCTTTGCGACCCACTACCATGAGTTG
ACTAGTCTGGAGTCTAGTTTACAACACTTGGTCAATGTCCACGTGGCAACTCTGGAGCAGGATGGGCAGGTTACCTTCCT
TCACAAGATTGAACCGGGACCAGCTGATAAATCCTACGGTATCCATGTTGCCAAGATTGCTGGCTTGCCAGCAGACCTTT
TAGCAAGGGCGGATAAGATTTTGACTCAGCTAGAGAATCAAGGAACAGAGAGTCCTCCTCCCATGAGACAAACTAGTGCT
GTCACTGAACAGATTTCACTCTTTGATAGGGCAGAAGAGCATCCTATCCTAGCAGAATTAGCTAAACTGGATGTGTATAA
TATGACACCTATGCAGGTTATGAATGTCTTAGTAGAGTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (256-546)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

3D structure

• AlphaFold DB: A4L7L6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	100	100	1
mutS	Pseudomonas stutzeri strain ATCC 17587	36.417	100	0.368