Detailed information NTG1021819

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: U2F28_RS10045
• Genome accession: NZ_CP160635
• Coordinates: 2015285..2016328 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN44
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2010285..2021328

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U2F28_RS10015 (U2F28_010015)	-	2010706..2011962 (-)	1257	WP_001795108.1	aminopeptidase	-
U2F28_RS10020 (U2F28_010020)	-	2011965..2012165 (-)	201	WP_000180460.1	DUF1128 family protein	-
U2F28_RS10025 (U2F28_010025)	-	2012312..2012776 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
U2F28_RS10030 (U2F28_010030)	-	2012783..2013058 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
U2F28_RS10035 (U2F28_010035)	-	2013336..2014553 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
U2F28_RS10040 (U2F28_010040)	vraR	2014666..2015295 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
U2F28_RS10045 (U2F28_010045)	vraS	2015285..2016328 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
U2F28_RS10050 (U2F28_010050)	liaF	2016325..2017026 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
U2F28_RS10055 (U2F28_010055)	-	2017041..2017427 (-)	387	WP_001110179.1	hypothetical protein	-
U2F28_RS10060 (U2F28_010060)	map	2017644..2018402 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
U2F28_RS10065 (U2F28_010065)	-	2018874..2019860 (+)	987	WP_000999710.1	aromatic acid exporter family protein	-
U2F28_RS10070 (U2F28_010070)	-	2020291..2020704 (-)	414	WP_001557448.1	hypothetical protein	-
U2F28_RS10075 (U2F28_010075)	-	2020733..2020843 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1021819 U2F28_RS10045 WP_001017131.1 2015285..2016328(-) (vraS) [Staphylococcus aureus strain BSN44]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1021819 U2F28_RS10045 WP_001017131.1 2015285..2016328(-) (vraS) [Staphylococcus aureus strain BSN44]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1