Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DQM61_RS08510 Genome accession   NZ_LS483379
Coordinates   1683925..1685907 (-) Length   660 a.a.
NCBI ID   WP_032467064.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10874     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1678925..1690907
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM61_RS08485 (NCTC10874_01676) recA 1678961..1680097 (-) 1137 WP_002992179.1 recombinase RecA -
  DQM61_RS08490 (NCTC10874_01677) cinA 1680186..1681457 (-) 1272 WP_002992182.1 competence/damage-inducible protein A Machinery gene
  DQM61_RS08495 (NCTC10874_01678) - 1681526..1682086 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  DQM61_RS08500 (NCTC10874_01679) ruvA 1682096..1682692 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA Machinery gene
  DQM61_RS08505 (NCTC10874_01680) - 1682694..1683914 (-) 1221 WP_023610269.1 MDR family MFS transporter -
  DQM61_RS08510 (NCTC10874_01681) hexB 1683925..1685907 (-) 1983 WP_032467064.1 DNA mismatch repair endonuclease MutL Machinery gene
  DQM61_RS08515 (NCTC10874_01682) - 1686002..1687153 (-) 1152 WP_003058754.1 tyrosine-type recombinase/integrase -
  DQM61_RS09265 - 1687402..1687545 (+) 144 WP_011185066.1 putative holin-like toxin -
  DQM61_RS08525 (NCTC10874_01684) - 1688428..1689108 (-) 681 WP_011185067.1 helix-turn-helix domain-containing protein -
  DQM61_RS08530 (NCTC10874_01685) - 1689272..1689469 (+) 198 WP_011185068.1 helix-turn-helix domain-containing protein -
  DQM61_RS08535 (NCTC10874_01686) - 1689483..1690091 (+) 609 WP_014407937.1 phage repressor protein -
  DQM61_RS08540 (NCTC10874_01687) - 1690112..1690519 (+) 408 WP_002992501.1 hypothetical protein -
  DQM61_RS09270 (NCTC10874_01688) - 1690532..1690654 (+) 123 WP_011285272.1 hypothetical protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74285.86 Da        Isoelectric Point: 5.8700

>NTDB_id=1021545 DQM61_RS08510 WP_032467064.1 1683925..1685907(-) (hexB) [Streptococcus pyogenes strain NCTC10874]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLVISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSIKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGDVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=1021545 DQM61_RS08510 WP_032467064.1 1683925..1685907(-) (hexB) [Streptococcus pyogenes strain NCTC10874]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGTTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAGTCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTTTCTGAAAAAATACCTGAGACTGATTTTTACTCCGGCGCTGTTGACAACAGTATAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGGGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCATGGGACTTATCTCTTTGCTCAAGGTAAAGATGGCTTATTT
ATTATCGATCAGCATGCTGCTCAAGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGCGACGTTGACAGTAGTTT
ACAGCAGCTATTGGTACCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTGCTTCTAACCAATGAGGTATCTATCAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(462-604)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.867

100

0.673