Detailed information NTG1017339

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABHI20_RS06505
• Genome accession: NZ_CP160045
• Coordinates: 1264785..1265822 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes M1 GAS strain SF370
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1259785..1270822

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABHI20_RS06485 (ABHI20_06485)	-	1260535..1261161 (+)	627	WP_010922497.1	A24 family peptidase	-
ABHI20_RS06490 (ABHI20_06490)	rlmN	1261243..1262322 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABHI20_RS06495 (ABHI20_06495)	-	1262326..1262946 (-)	621	WP_011285637.1	YutD family protein	-
ABHI20_RS06500 (ABHI20_06500)	-	1263394..1264371 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ABHI20_RS06505 (ABHI20_06505)	sepM	1264785..1265822 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABHI20_RS06510 (ABHI20_06510)	coaD	1265809..1266300 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABHI20_RS06515 (ABHI20_06515)	rsmD	1266290..1266829 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABHI20_RS06520 (ABHI20_06520)	asnA	1266952..1267944 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ABHI20_RS06525 (ABHI20_06525)	arcC	1268257..1269207 (-)	951	WP_010922501.1	carbamate kinase	-
ABHI20_RS06530 (ABHI20_06530)	-	1269227..1270558 (-)	1332	WP_010922502.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1017339 ABHI20_RS06505 WP_010922499.1 1264785..1265822(-) (sepM) [Streptococcus pyogenes M1 GAS strain SF370]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1017339 ABHI20_RS06505 WP_010922499.1 1264785..1265822(-) (sepM) [Streptococcus pyogenes M1 GAS strain SF370]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693