Detailed information NTG1016767

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQM44_RS09310
• Genome accession: NZ_LS483318
• Coordinates: 1847735..1848475 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1842735..1853475

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM44_RS09280 (NCTC5370_01905)	-	1843632..1844336 (-)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
DQM44_RS09290 (NCTC5370_01906)	rpmH	1844667..1844801 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
DQM44_RS09295 (NCTC5370_01907)	jag	1845115..1846029 (-)	915	WP_003062632.1	RNA-binding cell elongation regulator Jag/EloR	-
DQM44_RS09300 (NCTC5370_01908)	-	1846041..1846868 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
DQM44_RS09305 (NCTC5370_01909)	rnpA	1846834..1847193 (-)	360	WP_003056083.1	ribonuclease P protein component	-
DQM44_RS09310 (NCTC5370_01910)	comE/blpR	1847735..1848475 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
DQM44_RS09315 (NCTC5370_01911)	-	1848479..1849762 (-)	1284	WP_003056072.1	sensor histidine kinase	-
DQM44_RS09320 (NCTC5370_01912)	-	1849763..1851106 (-)	1344	WP_015058070.1	GHKL domain-containing protein	-
DQM44_RS09325 (NCTC5370_01913)	gltX	1851721..1853169 (-)	1449	WP_003053372.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=1016767 DQM44_RS09310 WP_003061418.1 1847735..1848475(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=1016767 DQM44_RS09310 WP_003061418.1 1847735..1848475(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTCTATTTGAGACTCCTCAGACAAGATTGAAACTACCTTACAAAGATATCCTT
TATTTTGCCACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394