Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   H1W81_RS03240 Genome accession   NZ_LR824002
Coordinates   607258..609357 (+) Length   699 a.a.
NCBI ID   WP_022096464.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_67     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 602258..614357
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W81_RS03210 (STHERMO_0696) yhbY 602363..602680 (+) 318 WP_002951701.1 ribosome assembly RNA-binding protein YhbY -
  H1W81_RS03215 (STHERMO_0697) - 602784..603416 (+) 633 WP_011226445.1 nicotinate-nucleotide adenylyltransferase -
  H1W81_RS03220 (STHERMO_0698) yqeK 603413..604003 (+) 591 WP_002951696.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
  H1W81_RS03225 (STHERMO_0699) rsfS 604027..604380 (+) 354 WP_011226444.1 ribosome silencing factor -
  H1W81_RS03230 (STHERMO_0700) - 604705..605445 (+) 741 WP_311316640.1 class I SAM-dependent methyltransferase -
  H1W81_RS03235 (STHERMO_0701) - 605452..606543 (+) 1092 WP_179971646.1 nucleotidyltransferase -
  H1W81_RS03240 (STHERMO_0702) clpE 607258..609357 (+) 2100 WP_022096464.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  H1W81_RS09765 (STHERMO_0703) - 609766..609891 (+) 126 WP_011681534.1 hypothetical protein -
  H1W81_RS03245 (STHERMO_0704) - 609910..610545 (+) 636 WP_011226440.1 DUF4230 domain-containing protein -
  H1W81_RS09440 (STHERMO_0705) - 610615..610785 (+) 171 WP_011226439.1 hypothetical protein -
  H1W81_RS03255 (STHERMO_0706) - 611337..611645 (-) 309 WP_011226438.1 hypothetical protein -
  H1W81_RS03260 (STHERMO_0707) - 611642..612061 (-) 420 WP_011226437.1 HIT family protein -
  H1W81_RS03265 (STHERMO_0708) pptA 612126..612857 (+) 732 WP_002951673.1 ABC transporter ATP-binding protein Regulator
  H1W81_RS03270 (STHERMO_0709) pptB 612857..613891 (+) 1035 WP_375708566.1 ABC transporter permease Regulator

Sequence

Protein


Download         Length: 699 a.a.        Molecular weight: 77167.06 Da        Isoelectric Point: 4.8564

>NTDB_id=1012143 H1W81_RS03240 WP_022096464.1 607258..609357(+) (clpE) [Streptococcus thermophilus isolate STH_CIRM_67]
MNNNFNNMDDLFNQLMGNMGGFRSESRRYMINGREVTPEEFAIYRQTGKLPGNQGEAVNPTQQHGPKQDGILAKLGRNLT
QEAREGKLDPVIGRNKEIQETSEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKDKEIISIDISALEAGT
QYRGSFEENIQNLVNEVKEAGNIILFFDEIHQILGAGSTGDGQGSKGLADILKPALSRGEITVIGATTQDEYRNTILKNA
ALARRFNEVKVNAPSPEDTFKILQGIRDLYEKHHNVILPDDVLKAAVDFSVQYIPQRSLPDKAIDLLDVTAAHLAAQHPV
TDVNAVEREIEEEKAKQEAAVAKEDYEAALNSKIRIEKLEKEIANHAKDRKVTATVNDVAESVERMTGIPVSQMGATDIE
RLKDMGNRLQAKVIGQDKAVEAVARSIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDLFGTKDAIIRLDMSEY
SDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVIIA
TSNAGFGYESNSTEDADKPELMDRLKPYFRPEFLNRFDAVIEFSHLDKEDLSKIVDLMLNEVNKTLSKKGIDLAVSEAAK
AYMTEEGYDEVMGARPLRRVVEQQIRDKVTDFHLDNLDAKHLEADMEDGVLVIKEKNAK

Nucleotide


Download         Length: 2100 bp        

>NTDB_id=1012143 H1W81_RS03240 WP_022096464.1 607258..609357(+) (clpE) [Streptococcus thermophilus isolate STH_CIRM_67]
ATGAACAACAACTTTAATAATATGGATGATCTTTTCAATCAATTGATGGGTAACATGGGTGGTTTCCGTTCAGAAAGCCG
TCGCTACATGATTAACGGTCGTGAAGTGACACCTGAAGAATTTGCAATTTACCGTCAAACAGGTAAATTGCCTGGTAATC
AAGGTGAAGCAGTGAACCCAACGCAACAACACGGACCTAAACAAGATGGTATTCTTGCTAAGCTTGGTCGTAACTTGACT
CAAGAAGCTCGTGAAGGTAAATTGGATCCTGTTATCGGACGTAACAAAGAAATCCAAGAAACTAGCGAAATCTTGGCTCG
TCGTACTAAGAATAACCCAGTCCTTGTCGGTGATGCTGGGGTTGGTAAAACAGCTGTAGTTGAAGGTTTGGCACAAGCCA
TCGTTAATGGTGATGTCCCAGCTGCTATCAAGGACAAAGAAATCATCTCAATTGATATTTCTGCACTTGAAGCTGGTACT
CAATACCGTGGTAGCTTTGAAGAAAACATTCAAAACTTGGTAAATGAAGTCAAAGAAGCTGGCAACATTATCCTCTTCTT
CGATGAAATTCATCAAATTCTTGGTGCCGGAAGCACTGGCGATGGTCAAGGTTCTAAAGGTCTGGCTGATATCTTGAAAC
CTGCTCTTTCACGTGGTGAAATAACAGTGATTGGTGCAACAACTCAAGATGAATACCGTAACACTATCTTGAAGAATGCT
GCCCTTGCTCGTCGTTTCAACGAAGTTAAGGTCAATGCTCCTTCTCCTGAAGATACCTTCAAGATTCTTCAAGGTATTCG
TGATCTTTATGAAAAACACCACAATGTTATCTTGCCAGATGATGTCTTGAAAGCAGCGGTTGATTTTTCAGTACAATACA
TTCCACAACGTAGCTTGCCAGATAAGGCTATTGACCTTTTGGACGTGACAGCAGCTCACTTGGCAGCACAACATCCAGTA
ACTGATGTCAATGCTGTTGAACGTGAAATCGAAGAAGAAAAAGCTAAACAAGAAGCTGCAGTTGCTAAAGAAGATTACGA
AGCAGCTCTAAATTCTAAGATTCGTATTGAAAAACTTGAAAAGGAAATTGCTAACCATGCAAAAGATCGCAAGGTGACTG
CGACTGTAAACGATGTGGCTGAATCCGTAGAACGTATGACTGGTATTCCAGTATCTCAAATGGGTGCAACGGATATCGAA
CGTTTGAAAGATATGGGTAACCGTTTGCAAGCTAAGGTTATCGGTCAAGATAAGGCCGTTGAAGCAGTGGCACGTTCCAT
CCGTCGTAATCGTGCAGGATTTGACGAAGGTAACCGTCCAATCGGTAGCTTCCTCTTTGTAGGACCTACTGGTGTTGGTA
AAACTGAGTTGGCTAAACAATTGGCCCTTGATTTGTTCGGTACCAAAGATGCTATCATCCGTTTGGACATGTCAGAATAC
AGCGACCGCACAGCCGTTTCTAAATTGATTGGTACAACAGCTGGTTATGTTGGTTATGATGATAATAGTAATACCTTGAC
AGAACGTGTTCGTCGTAACCCTTATTCAATCATCCTTCTTGATGAAATTGAAAAGGCAGACCCTCAAGTTATCACCCTTC
TCCTCCAAGTTTTGGATGATGGCCGTTTGACTGATGGTCAAGGTAATACTGTAAACTTCAAGAACACAGTCATTATCGCA
ACTTCAAACGCTGGCTTTGGTTACGAATCTAACTCGACAGAAGATGCTGATAAACCAGAACTCATGGATCGTTTGAAACC
TTACTTCCGTCCTGAATTCCTTAACCGTTTCGACGCAGTTATTGAGTTCTCACACTTAGATAAAGAGGACCTTTCTAAGA
TTGTCGATCTTATGTTGAATGAAGTTAACAAGACTCTTTCTAAGAAAGGCATTGACTTGGCAGTTAGCGAAGCTGCTAAA
GCCTATATGACAGAAGAAGGCTATGATGAAGTTATGGGTGCTCGTCCACTCCGTCGTGTGGTTGAACAACAAATCCGTGA
CAAAGTCACAGACTTCCACTTGGATAACCTTGATGCTAAACACCTAGAAGCTGATATGGAAGATGGTGTCTTAGTTATCA
AAGAAAAAAATGCTAAATAA

Domains

Predicted by InterProScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(606-676)

AAA domain (Cdc48 subfamily) (AAA_2)

(439-599)

ATPase family associated with various cellular activities (AAA) (AAA)

(114-246)

AAA lid domain (AAA_lid_9)

(255-349)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

46.724

100

0.469
  clpC Lactococcus lactis subsp. cremoris KW2

49.062

91.559

0.449
  clpE Streptococcus pneumoniae D39

48.657

90.558

0.441
  clpE Streptococcus pneumoniae Rx1

48.657

90.558

0.441
  clpE Streptococcus pneumoniae R6

48.657

90.558

0.441
  clpE Streptococcus pneumoniae TIGR4

48.576

90.415

0.439
  clpC Bacillus subtilis subsp. subtilis str. 168

46.13

92.418

0.426
  clpC Streptococcus thermophilus LMD-9

43.26

91.273

0.395
  clpC Streptococcus thermophilus LMG 18311

43.103

91.273

0.393
  clpC Streptococcus pneumoniae TIGR4

43.339

89.127

0.386
  clpC Streptococcus pneumoniae Rx1

43.339

89.127

0.386
  clpC Streptococcus pneumoniae D39

43.339

89.127

0.386
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

43.274

88.269

0.382
  clpC Streptococcus mutans UA159

42.995

88.841

0.382

Multiple sequence alignment