Detailed information NTG1010484

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W89_RS02000
• Genome accession: NZ_LR822029
• Coordinates: 368034..368819 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_1035
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 363034..373819

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W89_RS01975 (STHERMO_0399)	pflA	363310..364110 (+)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-
H1W89_RS01980 (STHERMO_0400)	-	364322..364696 (+)	375	WP_011681547.1	membrane protein	-
H1W89_RS01985 (STHERMO_0401)	-	364757..364930 (+)	174	WP_162835502.1	hypothetical protein	-
H1W89_RS09720	-	365002..365573 (-)	572	Protein_342	IS30 family transposase	-
H1W89_RS01990 (STHERMO_0404)	-	365753..366205 (-)	453	WP_002946987.1	universal stress protein	-
H1W89_RS01995 (STHERMO_0405)	-	366560..367774 (+)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
H1W89_RS02000 (STHERMO_0406)	codY	368034..368819 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W89_RS02005 (STHERMO_0407)	-	368882..369433 (+)	552	WP_002946999.1	cysteine hydrolase family protein	-
H1W89_RS02010 (STHERMO_0408)	-	369557..370405 (+)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W89_RS02015 (STHERMO_0409)	msrA	370417..370926 (+)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W89_RS02020	-	371079..372523 (+)	1445	Protein_349	6-phospho-beta-glucosidase	-
H1W89_RS02025 (STHERMO_0412)	-	372887..373048 (+)	162	WP_224102937.1	glycosyltransferase	-
H1W89_RS02030 (STHERMO_0413)	-	373061..373315 (+)	255	WP_024010053.1	glycosyl transferase	-
H1W89_RS02035 (STHERMO_0414)	gatC	373455..373757 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1010484 H1W89_RS02000 WP_002951720.1 368034..368819(+) (codY) [Streptococcus thermophilus isolate STH_CIRM_1035]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1010484 H1W89_RS02000 WP_002951720.1 368034..368819(+) (codY) [Streptococcus thermophilus isolate STH_CIRM_1035]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502