Detailed information NTG1010353

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: H1X63_RS00325
• Genome accession: NZ_LR822027
• Coordinates: 55561..58119 (+)
• Length: 852 a.a.
• NCBI ID: WP_179972480.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_998
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 50561..63119

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X63_RS00300 (STHERMO_0051)	purB	50774..52072 (+)	1299	WP_179972478.1	adenylosuccinate lyase	-
H1X63_RS00305 (STHERMO_0052)	-	52226..52396 (+)	171	WP_179971878.1	hypothetical protein	-
H1X63_RS00310 (STHERMO_0053)	argS	52935..54626 (-)	1692	WP_179972479.1	arginine--tRNA ligase	-
H1X63_RS00315 (STHERMO_0054)	argR	54781..55209 (+)	429	WP_024704313.1	arginine repressor	-
H1X63_RS00320 (STHERMO_0055)	-	55209..55568 (+)	360	WP_064355739.1	YlbF family regulator	-
H1X63_RS00325 (STHERMO_0056)	hexA	55561..58119 (+)	2559	WP_179972480.1	DNA mismatch repair protein MutS	Machinery gene
H1X63_RS00330 (STHERMO_0057)	-	58153..58608 (-)	456	WP_179972481.1	DUF3021 domain-containing protein	-
H1X63_RS00335 (STHERMO_0058)	-	58605..59042 (-)	438	WP_002886318.1	LytTR family DNA-binding domain-containing protein	-
H1X63_RS00340 (STHERMO_0059)	-	59221..59526 (+)	306	WP_179972482.1	hypothetical protein	-
H1X63_RS00345 (STHERMO_0060)	hexB	59578..61521 (+)	1944	WP_011680601.1	DNA mismatch repair endonuclease MutL	Machinery gene
H1X63_RS00350 (STHERMO_0061)	-	61652..61873 (+)	222	WP_011680602.1	hypothetical protein	-
H1X63_RS00355 (STHERMO_0062)	ruvA	62025..62615 (+)	591	WP_111679083.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95410.68 Da
• Isoelectric Point: 4.6769

>NTDB_id=1010353 H1X63_RS00325 WP_179972480.1 55561..58119(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_998]
MAKEKISPGMQQYLDIKENYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLILSKETEGYDDVHLIDNSLTDLESSVAGKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDETKTAMGTRLLRTWIDRPLVNQATIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGRTLAQVPVIKAILESFNDNALSGLLQELDALPELESLICSAIDP
EAPATITEGGIIRAGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAEKNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPIFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPIDLLNRADTILTQLEGETVVIQPEEKVSSQ
EKPAIETHVNEQIPLFGDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=1010353 H1X63_RS00325 WP_179972480.1 55561..58119(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_998]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGGAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTATTAAGGCTGCCCAGATTTTAGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCTATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTGATTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGATAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCGGGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGTAAGAAACATGGTTCTCTTTTCTGGCTCTTGGATGAAACCAAGACAGCCATGGGAACGCGTCTTTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCACCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTGATTCAGCTAGGTCGTACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACAATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTTGTTCGGCTATTGATCCT
GAAGCTCCAGCAACAATTACAGAAGGTGGTATTATCCGTGCTGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCCAAAGAACGTGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTATTTCCATGTGACCAACTCTAACCTTAGCTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCGCGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAAGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCGACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGAAAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCAATTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTGGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCCGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAATAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTGAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCCCTCTCTTTGGTGACTTTACTGAAAATCCAGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain II (MutS_II) (126-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.592	100	0.736
mutS	Pseudomonas stutzeri strain ATCC 17587	36.018	100	0.367