Detailed information NTG1009911

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: H0514_RS00325
• Genome accession: NZ_LR822020
• Coordinates: 55560..58118 (+)
• Length: 852 a.a.
• NCBI ID: WP_179972480.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_956
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 50560..63118

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0514_RS00300 (STHERMO_0055)	purB	50773..52071 (+)	1299	WP_179972478.1	adenylosuccinate lyase	-
H0514_RS00305 (STHERMO_0056)	-	52225..52395 (+)	171	WP_179971878.1	hypothetical protein	-
H0514_RS00310 (STHERMO_0057)	argS	52934..54625 (-)	1692	WP_179972479.1	arginine--tRNA ligase	-
H0514_RS00315 (STHERMO_0058)	argR	54780..55208 (+)	429	WP_024704313.1	arginine repressor	-
H0514_RS00320 (STHERMO_0059)	-	55208..55567 (+)	360	WP_064355739.1	YlbF family regulator	-
H0514_RS00325 (STHERMO_0060)	hexA	55560..58118 (+)	2559	WP_179972480.1	DNA mismatch repair protein MutS	Machinery gene
H0514_RS00330 (STHERMO_0061)	-	58152..58607 (-)	456	WP_179972481.1	DUF3021 domain-containing protein	-
H0514_RS00335 (STHERMO_0062)	-	58604..59041 (-)	438	WP_002886318.1	LytTR family DNA-binding domain-containing protein	-
H0514_RS00340 (STHERMO_0063)	-	59220..59525 (+)	306	WP_179972482.1	hypothetical protein	-
H0514_RS00345 (STHERMO_0064)	hexB	59577..61520 (+)	1944	WP_011680601.1	DNA mismatch repair endonuclease MutL	Machinery gene
H0514_RS00350 (STHERMO_0065)	-	61651..61872 (+)	222	WP_011680602.1	hypothetical protein	-
H0514_RS00355 (STHERMO_0066)	ruvA	62024..62614 (+)	591	WP_111679083.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95410.68 Da
• Isoelectric Point: 4.6769

>NTDB_id=1009911 H0514_RS00325 WP_179972480.1 55560..58118(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_956]
MAKEKISPGMQQYLDIKENYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLILSKETEGYDDVHLIDNSLTDLESSVAGKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDETKTAMGTRLLRTWIDRPLVNQATIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGRTLAQVPVIKAILESFNDNALSGLLQELDALPELESLICSAIDP
EAPATITEGGIIRAGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAEKNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPIFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPIDLLNRADTILTQLEGETVVIQPEEKVSSQ
EKPAIETHVNEQIPLFGDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=1009911 H0514_RS00325 WP_179972480.1 55560..58118(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_956]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGGAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTATTAAGGCTGCCCAGATTTTAGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCTATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTGATTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGATAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCGGGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGTAAGAAACATGGTTCTCTTTTCTGGCTCTTGGATGAAACCAAGACAGCCATGGGAACGCGTCTTTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCACCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTGATTCAGCTAGGTCGTACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACAATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTTGTTCGGCTATTGATCCT
GAAGCTCCAGCAACAATTACAGAAGGTGGTATTATCCGTGCTGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCCAAAGAACGTGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTATTTCCATGTGACCAACTCTAACCTTAGCTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCGCGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAAGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCGACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGAAAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCAATTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTGGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCCGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAATAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTGAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCCCTCTCTTTGGTGACTTTACTGAAAATCCAGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain II (MutS_II) (126-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.592	100	0.736
mutS	Pseudomonas stutzeri strain ATCC 17587	36.018	100	0.367