Detailed information NTG1009502

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: H0508_RS00325
• Genome accession: NZ_LR822014
• Coordinates: 56697..59255 (+)
• Length: 852 a.a.
• NCBI ID: WP_011225278.1
• Uniprot ID: Q5M6I1
• Organism: Streptococcus thermophilus isolate STH_CIRM_36
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 51697..64255

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0508_RS00305 (STHERMO_0056)	-	52473..53426 (-)	954	WP_041826943.1	IS30 family transposase	-
H0508_RS00310 (STHERMO_0057)	argS	54071..55762 (-)	1692	WP_011225275.1	arginine--tRNA ligase	-
H0508_RS00315 (STHERMO_0058)	argR	55917..56345 (+)	429	WP_024704313.1	arginine repressor	-
H0508_RS00320 (STHERMO_0059)	-	56345..56704 (+)	360	WP_011225277.1	YlbF family regulator	-
H0508_RS00325 (STHERMO_0060)	hexA	56697..59255 (+)	2559	WP_011225278.1	DNA mismatch repair protein MutS	Machinery gene
H0508_RS09870	-	59289..59744 (-)	456	Protein_44	DUF3021 domain-containing protein	-
H0508_RS00335 (STHERMO_0063)	-	59741..60132 (-)	392	Protein_45	LytTR family DNA-binding domain-containing protein	-
H0508_RS00340 (STHERMO_0064)	-	60356..60661 (+)	306	WP_011225281.1	hypothetical protein	-
H0508_RS00345 (STHERMO_0065)	hexB	60713..62656 (+)	1944	WP_011225282.1	DNA mismatch repair endonuclease MutL	Machinery gene
H0508_RS00350 (STHERMO_0066)	-	62786..63007 (+)	222	WP_041826940.1	hypothetical protein	-
H0508_RS00355 (STHERMO_0067)	ruvA	63159..63749 (+)	591	WP_002949053.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95467.73 Da
• Isoelectric Point: 4.7412

>NTDB_id=1009502 H0508_RS00325 WP_011225278.1 56697..59255(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_36]
MAKEKISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKETEGYDDVHLIGNSLTDLESSVASKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDKTKTAMGMRLLRTWIDRPLVNQASIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPVIKAILESFNDDALSGLLQELDALPELESLIRSAIDP
DAPATITEGGIIRDGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAETNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPVFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPTDLLNRADTILTQLEGETVVIQPQEKVLSQ
EKPAIETHVNEQISLFDDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=1009502 H0508_RS00325 WP_011225278.1 56697..59255(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_36]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGAAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTGTTAAGGCTGCCCAGATTTTGGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCAAGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATAAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCAGCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTAATTCAGCTAGGTCATACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCGTTCGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATTCGTGATGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCAAAAGAACGCGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTACTTCCATGTGACCAACTCTAACCTTAGTTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCACGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAGGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCAACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGACAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCTGTTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTTGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCCGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAACAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTCAGGAAAAGGTATTGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCTCTCTCTTTGATGATTTTACTGAAAATCCGGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS domain II (MutS_II) (126-239)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain V (MutS_V) (599-785)

3D structure

• AlphaFold DB: Q5M6I1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.944	100	0.739
mutS	Pseudomonas stutzeri strain ATCC 17587	35.788	100	0.365