Detailed information NTG1008959

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H0501_RS07775
• Genome accession: NZ_LR822008
• Coordinates: 1509025..1509810 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_18
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1504025..1514810

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0501_RS07745 (STHERMO_1716)	gatC	1504092..1504394 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H0501_RS10110 (STHERMO_1718)	-	1504726..1504998 (-)	273	WP_232085675.1	glycosyltransferase	-
H0501_RS07755 (STHERMO_1719)	-	1505325..1506766 (-)	1442	Protein_1491	6-phospho-beta-glucosidase	-
H0501_RS07760 (STHERMO_1720)	msrA	1506919..1507428 (-)	510	WP_041827768.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H0501_RS07765 (STHERMO_1721)	-	1507440..1508288 (-)	849	WP_011681545.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H0501_RS07770 (STHERMO_1722)	-	1508411..1508962 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H0501_RS07775 (STHERMO_1723)	codY	1509025..1509810 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H0501_RS07780 (STHERMO_1724)	-	1510070..1511284 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H0501_RS07785 (STHERMO_1725)	-	1511639..1512091 (+)	453	WP_179970584.1	universal stress protein	-
H0501_RS10115	-	1512273..1512844 (+)	572	Protein_1498	IS30 family transposase	-
H0501_RS10120 (STHERMO_1727)	-	1512916..1513512 (-)	597	WP_232086461.1	hypothetical protein	-
H0501_RS07795 (STHERMO_1729)	pflA	1513724..1514524 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1008959 H0501_RS07775 WP_002951720.1 1509025..1509810(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_18]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1008959 H0501_RS07775 WP_002951720.1 1509025..1509810(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_18]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502