Detailed information NTG1007223

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABLU29_RS03860
• Genome accession: NZ_CP157498
• Coordinates: 666858..667886 (+)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis strain 2B-5
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 661858..672886

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABLU29_RS03835 (ABLU29_03825)	-	662405..662899 (-)	495	WP_017865181.1	RNA polymerase sigma factor	-
ABLU29_RS03840 (ABLU29_03830)	lmrP	663087..664313 (+)	1227	Protein_632	multidrug efflux MFS transporter LmrP	-
ABLU29_RS03845 (ABLU29_03835)	-	664396..665616 (+)	1221	WP_003132654.1	MFS transporter	-
ABLU29_RS03850 (ABLU29_03840)	rsmD	665787..666326 (+)	540	WP_015427191.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABLU29_RS03855 (ABLU29_03845)	coaD	666374..666871 (+)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
ABLU29_RS03860 (ABLU29_03850)	sepM	666858..667886 (+)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
ABLU29_RS03865 (ABLU29_03855)	-	668208..668321 (+)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
ABLU29_RS03870 (ABLU29_03860)	kwcM	668389..669708 (+)	1320	WP_058207975.1	KxxxW cyclic peptide radical SAM maturase	-
ABLU29_RS03875 (ABLU29_03865)	-	669792..670193 (+)	402	WP_406841034.1	MFS transporter	-
ABLU29_RS03880 (ABLU29_03870)	-	670954..671811 (+)	858	WP_058203259.1	Rgg/GadR/MutR family transcriptional regulator	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=1007223 ABLU29_RS03860 WP_003132657.1 666858..667886(+) (sepM) [Lactococcus lactis strain 2B-5]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=1007223 ABLU29_RS03860 WP_003132657.1 666858..667886(+) (sepM) [Lactococcus lactis strain 2B-5]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACGAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGGAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTATAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGCGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
AACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTAGTGCCTGACTCAGGCACCAAAAAGGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCAGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491