Detailed information NTG1007175

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABLU28_RS03425
• Genome accession: NZ_CP157495
• Coordinates: 666859..667887 (+)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis strain 2B-1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 661859..672887

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABLU28_RS03400 (ABLU28_03400)	-	662406..662900 (-)	495	WP_406840953.1	RNA polymerase sigma factor	-
ABLU28_RS03405 (ABLU28_03405)	lmrP	663088..664314 (+)	1227	Protein_629	multidrug efflux MFS transporter LmrP	-
ABLU28_RS03410 (ABLU28_03410)	-	664397..665617 (+)	1221	WP_003132654.1	MFS transporter	-
ABLU28_RS03415 (ABLU28_03415)	rsmD	665788..666327 (+)	540	WP_015427191.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABLU28_RS03420 (ABLU28_03420)	coaD	666375..666872 (+)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
ABLU28_RS03425 (ABLU28_03425)	sepM	666859..667887 (+)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
ABLU28_RS03430 (ABLU28_03430)	-	668209..668322 (+)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
ABLU28_RS03435 (ABLU28_03435)	kwcM	668390..669709 (+)	1320	WP_058207975.1	KxxxW cyclic peptide radical SAM maturase	-
ABLU28_RS03440 (ABLU28_03440)	-	669793..670194 (+)	402	WP_406841034.1	MFS transporter	-
ABLU28_RS03445 (ABLU28_03445)	-	670955..671584 (+)	630	WP_406834870.1	transcriptional regulator	-
ABLU28_RS03450 (ABLU28_03450)	-	671594..671812 (+)	219	WP_406834868.1	hypothetical protein	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=1007175 ABLU28_RS03425 WP_003132657.1 666859..667887(+) (sepM) [Lactococcus lactis strain 2B-1]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=1007175 ABLU28_RS03425 WP_003132657.1 666859..667887(+) (sepM) [Lactococcus lactis strain 2B-1]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACGAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGGAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTATAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGCGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
AACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTAGTGCCTGACTCAGGCACCAAAAAGGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCAGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491