Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   UXQ44_RS00185 Genome accession   NZ_CP157308
Coordinates   41280..42641 (-) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus aureus strain BSN82     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39655..68563 41280..42641 within 0


Gene organization within MGE regions


Location: 39655..68563
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UXQ44_RS00180 (UXQ44_00180) ccrB 39655..41283 (-) 1629 WP_001631035.1 recombinase family protein Machinery gene
  UXQ44_RS00185 (UXQ44_00185) ccrA 41280..42641 (-) 1362 WP_001631036.1 recombinase family protein Machinery gene
  UXQ44_RS00190 (UXQ44_00190) - 42828..43457 (-) 630 Protein_35 hypothetical protein -
  UXQ44_RS00195 (UXQ44_00195) - 43466..43804 (+) 339 Protein_36 recombinase family protein -
  UXQ44_RS00200 (UXQ44_00200) - 43916..44275 (-) 360 WP_196499687.1 hypothetical protein -
  UXQ44_RS00205 (UXQ44_00205) - 44482..44808 (+) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  UXQ44_RS00210 (UXQ44_00210) - 45138..47063 (+) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  UXQ44_RS00215 (UXQ44_00215) - 48289..49545 (+) 1257 WP_149590267.1 DUF3578 domain-containing protein -
  UXQ44_RS00220 (UXQ44_00220) - 49960..50199 (+) 240 WP_001282728.1 hypothetical protein -
  UXQ44_RS00225 (UXQ44_00225) - 50231..50905 (-) 675 WP_001105987.1 IS6-like element IS257 family transposase -
  UXQ44_RS00230 (UXQ44_00230) - 50989..51330 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  UXQ44_RS00235 (UXQ44_00235) - 52207..52950 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  UXQ44_RS00240 (UXQ44_00240) - 53047..53475 (+) 429 WP_000872606.1 MaoC family dehydratase -
  UXQ44_RS00245 (UXQ44_00245) mecA 53521..55530 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  UXQ44_RS00250 (UXQ44_00250) - 55627..56613 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  UXQ44_RS00255 (UXQ44_00255) - 56603..56844 (+) 242 Protein_48 type I restriction enzyme endonuclease domain-containing protein -
  UXQ44_RS00260 (UXQ44_00260) - 56835..58442 (-) 1608 Protein_49 IS1182 family transposase -
  UXQ44_RS00265 (UXQ44_00265) - 58494..59000 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  UXQ44_RS00270 (UXQ44_00270) - 59015..59326 (-) 312 WP_000700851.1 DUF960 family protein -
  UXQ44_RS00275 (UXQ44_00275) - 59413..59763 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  UXQ44_RS00280 (UXQ44_00280) ccrB 60285..61913 (-) 1629 WP_001186608.1 recombinase family protein Machinery gene
  UXQ44_RS00285 (UXQ44_00285) ccrA 61935..63284 (-) 1350 WP_031806890.1 recombinase family protein Machinery gene
  UXQ44_RS00290 (UXQ44_00290) - 63518..65311 (-) 1794 WP_031806891.1 DUF927 domain-containing protein -
  UXQ44_RS00295 (UXQ44_00295) - 65311..65604 (-) 294 WP_001587828.1 single-stranded DNA-binding protein -
  UXQ44_RS00300 (UXQ44_00300) - 65839..66978 (+) 1140 Protein_57 IS3 family transposase -
  UXQ44_RS00305 (UXQ44_00305) - 67049..68563 (-) 1515 WP_001587831.1 hypothetical protein -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=1005750 UXQ44_RS00185 WP_001631036.1 41280..42641(-) (ccrA) [Staphylococcus aureus strain BSN82]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=1005750 UXQ44_RS00185 WP_001631036.1 41280..42641(-) (ccrA) [Staphylococcus aureus strain BSN82]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494

Multiple sequence alignment