Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   FGK81_RS00560 Genome accession   NZ_LR590466
Coordinates   103996..105978 (+) Length   660 a.a.
NCBI ID   WP_011889221.1    Uniprot ID   A2RGV3
Organism   Streptococcus pyogenes strain NCTC8193     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 98996..110978
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK81_RS00535 (NCTC8193_00107) - 99555..99788 (-) 234 WP_011889225.1 helix-turn-helix domain-containing protein -
  FGK81_RS10170 - 99943..100180 (+) 238 Protein_88 helix-turn-helix domain-containing protein -
  FGK81_RS00545 (NCTC8193_00109) - 101250..101525 (+) 276 WP_011889223.1 helix-turn-helix transcriptional regulator -
  FGK81_RS00550 (NCTC8193_00110) - 101551..102540 (+) 990 WP_011889222.1 DUF3644 domain-containing protein -
  FGK81_RS00555 (NCTC8193_00112) - 102884..103901 (+) 1018 Protein_91 tyrosine-type recombinase/integrase -
  FGK81_RS00560 (NCTC8193_00113) hexB 103996..105978 (+) 1983 WP_011889221.1 DNA mismatch repair endonuclease MutL Machinery gene
  FGK81_RS00565 (NCTC8193_00114) - 105989..107209 (+) 1221 WP_011018316.1 MDR family MFS transporter -
  FGK81_RS00570 (NCTC8193_00115) ruvA 107211..107807 (+) 597 WP_011185063.1 Holliday junction branch migration protein RuvA Machinery gene
  FGK81_RS00575 (NCTC8193_00116) - 107817..108377 (+) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  FGK81_RS00580 (NCTC8193_00117) cinA 108446..109717 (+) 1272 WP_011018313.1 competence/damage-inducible protein A Machinery gene
  FGK81_RS00585 (NCTC8193_00118) recA 109806..110942 (+) 1137 WP_002982186.1 recombinase RecA -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74374.96 Da        Isoelectric Point: 5.8725

>NTDB_id=1004603 FGK81_RS00560 WP_011889221.1 103996..105978(+) (hexB) [Streptococcus pyogenes strain NCTC8193]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYFGAVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLNRLENEEKSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEADSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=1004603 FGK81_RS00560 WP_011889221.1 103996..105978(+) (hexB) [Streptococcus pyogenes strain NCTC8193]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCACCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTTTCTGAAAAAATACCTGAAACTGATTTTTATTTCGGTGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCAGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGTTGAATCGCTTGGAAAATGAAGAAA
AATCAGTATTTCCTGAATTGGATTATTTTGGTCAGATGCATGGGACTTATCTCTTTGCTCAAGGTAAAGATGGCTTATTT
ATTATCGATCAGCATGCTGCTCAAGAGCGGGTTAAATACGAATATTATCGTGATAAGATAGGTGAGGCTGACAGTAGTTT
GCAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATCAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(462-604)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RGV3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.867

100

0.673