Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1020969..1022206 Replicon chromosome
Accession NZ_CP027540
Organism Streptococcus pneumoniae strain D39V

Toxin (Protein)


Gene name pezT Uniprot ID R4H7C0
Locus tag SPV_RS05325 Protein ID WP_000405357.1
Coordinates 1020969..1021730 (-) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag SPV_RS05330 Protein ID WP_000579612.1
Coordinates 1021730..1022206 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPV_RS11360 1016347..1018232 - 1886 Protein_985 relaxase/mobilization nuclease domain-containing protein -
SPV_RS05305 1018255..1018584 - 330 WP_000263037.1 MobC family plasmid mobilization relaxosome protein -
SPV_RS05310 1018594..1018953 - 360 WP_000529543.1 hypothetical protein -
SPV_RS05320 1019785..1020941 - 1157 Protein_988 hypothetical protein -
SPV_RS05325 1020969..1021730 - 762 WP_000405357.1 zeta toxin family protein Toxin
SPV_RS05330 1021730..1022206 - 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
SPV_RS05335 1022651..1022932 - 282 WP_000266233.1 hypothetical protein -
SPV_RS05340 1022978..1023295 - 318 WP_000995820.1 hypothetical protein -
SPV_RS05345 1023381..1025120 - 1740 WP_000423451.1 glycoside hydrolase family 13 protein -
SPV_RS05350 1025283..1026167 - 885 WP_000710119.1 diacylglycerol kinase family lipid kinase -
SPV_RS05355 1026279..1027133 - 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1002494..1037461 34967


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29044.10 Da        Isoelectric Point: 7.1307

>T99264 WP_000405357.1 NZ_CP027540:c1021730-1020969 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T99264 NZ_CP027540:c1021730-1020969 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT99264 WP_000579612.1 NZ_CP027540:c1022206-1021730 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT99264 NZ_CP027540:c1022206-1021730 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACAGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R4H7C0

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References