98157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1210307..1210678 Replicon chromosome
Accession NZ_CP027347
Organism Escherichia coli strain 2013C-4361

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag AZF34_RS06645 Protein ID WP_001443846.1
Coordinates 1210529..1210678 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1210307..1210485 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZF34_RS06620 1206262..1207635 + 1374 WP_000123745.1 ATP-dependent RNA helicase DbpA -
AZF34_RS06625 1207764..1208699 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
AZF34_RS06630 1208751..1209986 - 1236 WP_000040839.1 site-specific integrase -
AZF34_RS06635 1209988..1210203 - 216 WP_000079604.1 excisionase XisR -
AZF34_RS06640 1210303..1210491 - 189 WP_001302840.1 DUF1187 family protein -
- 1210307..1210485 + 179 NuclAT_0 - Antitoxin
- 1210307..1210485 + 179 NuclAT_0 - Antitoxin
- 1210307..1210485 + 179 NuclAT_0 - Antitoxin
- 1210307..1210485 + 179 NuclAT_0 - Antitoxin
AZF34_RS06645 1210529..1210678 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
AZF34_RS06650 1210734..1211543 - 810 WP_000166313.1 recombination protein RecT -
AZF34_RS06655 1211536..1214136 - 2601 WP_000105140.1 exodeoxyribonuclease VIII -
AZF34_RS06660 1214238..1214513 - 276 WP_001344816.1 hypothetical protein -
AZF34_RS06665 1214588..1214758 - 171 WP_001352098.1 conserved protein, Rac prophage -
AZF34_RS06670 1214758..1214979 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1208751..1260524 51773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T98157 WP_001443846.1 NZ_CP027347:c1210678-1210529 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

>T98157 NZ_CP027347:c1210678-1210529 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin


Download         Length: 179 bp

>AT98157 NZ_CP027347:1210307-1210485 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References