Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB-PIN
Location 2833113..2833719 Replicon chromosome
Accession NC_002754
Organism Sulfolobus solfataricus P2

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SSO_RS14920 Protein ID WP_009989090.1
Coordinates 2833113..2833517 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SSO_RS14925 Protein ID WP_009989091.1
Coordinates 2833498..2833719 (-) Length 74 a.a.

Genomic Context

SSO_RS14905SSO_RS14910SSO_RS15820SSO_RS17230SSO_RS14930SSO_RS14935SSO_RS14940SSO_RS14945SSO_RS14895SSO_RS14900SSO_RS17225SSO_RS14920SSO_RS14925SSO_RS14950SSO_RS14955
Location: 2830542..2831321 (780 bp)
Type: Others
Protein ID: WP_014511459.1
Location: 2831759..2832483 (725 bp)
Type: Others
Protein ID: Protein_2988
Location: 2832708..2832917 (210 bp)
Type: Others
Protein ID: Protein_2990
Location: 2833968..2834108 (141 bp)
Type: Others
Protein ID: WP_010924124.1
Location: 2834248..2834448 (201 bp)
Type: Others
Protein ID: WP_009989095.1
Location: 2834502..2834732 (231 bp)
Type: Others
Protein ID: WP_009989096.1
Location: 2834843..2836114 (1272 bp)
Type: Others
Protein ID: WP_009989097.1
Location: 2836233..2836898 (666 bp)
Type: Others
Protein ID: WP_009989098.1
Location: 2828615..2829376 (762 bp)
Type: Others
Protein ID: WP_009990867.1
Location: 2829524..2829706 (183 bp)
Type: Others
Protein ID: WP_009990866.1
Location: 2832481..2832588 (108 bp)
Type: Others
Protein ID: Protein_2989
Location: 2833113..2833517 (405 bp)
Type: Toxin
Protein ID: WP_009989090.1
Location: 2833498..2833719 (222 bp)
Type: Antitoxin
Protein ID: WP_009989091.1
Location: 2836895..2837281 (387 bp)
Type: Others
Protein ID: WP_009989099.1
Location: 2837278..2837895 (618 bp)
Type: Others
Protein ID: WP_009989100.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSO_RS14895 (SSO3073)2828615..2829376-762WP_009990867.1ZIP family metal transporter-
SSO_RS149002829524..2829706-183WP_009990866.1hypothetical protein-
SSO_RS14905 (SSO3074)2830542..2831321+780WP_014511459.1DMT family transporter-
SSO_RS149102831759..2832483+725Protein_2988transposase-
SSO_RS172252832481..2832588-108Protein_2989IS110 family transposase-
SSO_RS15820 (SSO11909)2832708..2832917+210Protein_2990transposase-
SSO_RS14920 (SSO3078)2833113..2833517-405WP_009989090.1PIN domain-containing proteinToxin
SSO_RS14925 (SSO11914)2833498..2833719-222WP_009989091.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SSO_RS17230 (SSO11915)2833968..2834108+141WP_010924124.1hypothetical protein-
SSO_RS14930 (SSO11917)2834248..2834448+201WP_009989095.1hypothetical protein-
SSO_RS14935 (SSO11920)2834502..2834732+231WP_009989096.1EamA family transporter-
SSO_RS14940 (SSO3079)2834843..2836114+1272WP_009989097.1MFS transporter-
SSO_RS14945 (SSO3080)2836233..2836898+666WP_009989098.1helix-turn-helix domain-containing protein-
SSO_RS14950 (SSO3081)2836895..2837281-387WP_009989099.1hypothetical protein-
SSO_RS14955 (SSO3082)2837278..2837895-618WP_009989100.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T956 WP_009989090.1 NC_002754:c2833517-2833113 [Saccharolobus solfataricus P2]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T956 NC_002754:c2833517-2833113 [Saccharolobus solfataricus P2]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT956 WP_009989091.1 NC_002754:c2833719-2833498 [Saccharolobus solfataricus P2]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT956 NC_002754:c2833719-2833498 [Saccharolobus solfataricus P2]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T947Sulfolobus solfataricus P2

36.364

96.032

0.349
Showing 1 to 1 of 1 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT947Sulfolobus solfataricus P2

50

93.151

0.466

AT951Sulfolobus solfataricus P2

34.247

100

0.342
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3K068

Antitoxin

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Source
ID
Structure
AlphaFold DBM9UBQ9

References

(1) Charlotte R Cooper et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society Transactions 37(Pt 1):123-6. [PubMed:19143615] experimental

(2) Sabrina Tachdjian et al. (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of Bacteriology 188(12):4553-9. [PubMed:16740961] experimental


experimental experimental literature