Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB-PIN |
| Location | 1511957..1512542 | Replicon | chromosome |
| Accession | NC_002754 | ||
| Organism | Sulfolobus solfataricus P2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | SSO_RS08045 | Protein ID | WP_010923552.1 |
| Coordinates | 1512162..1512542 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q97XQ3 |
| Locus tag | SSO_RS08040 | Protein ID | WP_009989998.1 |
| Coordinates | 1511957..1512196 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SSO_RS08025 (SSO1654) | 1508573..1509523 | - | 951 | WP_048054236.1 | IS1 family transposase | - |
| SSO_RS08030 (SSO1655) | 1509686..1510060 | + | 375 | WP_010923551.1 | C-terminal helicase domain-containing protein | - |
| SSO_RS08035 (SSO1656) | 1510060..1510713 | + | 654 | WP_009991009.1 | SWIM zinc finger family protein | - |
| SSO_RS08040 (SSO8620) | 1511957..1512196 | + | 240 | WP_009989998.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SSO_RS08045 (SSO1657) | 1512162..1512542 | + | 381 | WP_010923552.1 | PIN domain-containing protein | Toxin |
| SSO_RS08050 (SSO1658) | 1512757..1513338 | + | 582 | WP_010923553.1 | IS607 family transposase | - |
| SSO_RS08055 (SSO1659) | 1513316..1514584 | + | 1269 | WP_010923554.1 | RNA-guided endonuclease TnpB family protein | - |
| SSO_RS16335 | 1514659..1514949 | + | 291 | WP_009990096.1 | hypothetical protein | - |
| SSO_RS08065 (SSO1662) | 1515235..1516986 | - | 1752 | WP_009990097.1 | hydantoinase B/oxoprolinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 1492953..1514584 | 21631 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14708.16 Da Isoelectric Point: 4.8546
>T947 WP_010923552.1 NC_002754:1512162-1512542 [Saccharolobus solfataricus P2]
MRLEEKLQTVVDTNFIIAIIFRDHEKHEEALKEWEIIEKAYLPLISLSELSYFLIKNGVNLEVVNEVISDPKIEIVPNTI
EDVRFALANKEKIKGYDDFNDFLILSTAKRLDLPLLTFDKKLKMKS
MRLEEKLQTVVDTNFIIAIIFRDHEKHEEALKEWEIIEKAYLPLISLSELSYFLIKNGVNLEVVNEVISDPKIEIVPNTI
EDVRFALANKEKIKGYDDFNDFLILSTAKRLDLPLLTFDKKLKMKS
Download Length: 381 bp
>T947 NC_002754:1512162-1512542 [Saccharolobus solfataricus P2]
ATGAGGCTGGAAGAGAAATTGCAGACAGTAGTTGATACAAATTTTATAATAGCCATAATTTTTAGGGACCATGAGAAACA
TGAAGAAGCATTAAAGGAATGGGAAATTATTGAAAAAGCTTACTTGCCCCTAATTTCACTATCAGAACTCTCCTATTTTC
TAATAAAAAACGGCGTGAATCTTGAAGTAGTAAATGAGGTAATAAGCGATCCGAAAATTGAGATAGTCCCAAATACAATA
GAGGACGTTCGTTTTGCGTTAGCTAACAAAGAGAAAATAAAGGGATATGACGATTTTAACGACTTCCTAATACTCTCAAC
AGCTAAAAGGCTCGATCTACCTTTACTTACTTTTGATAAAAAACTGAAAATGAAAAGTTAA
ATGAGGCTGGAAGAGAAATTGCAGACAGTAGTTGATACAAATTTTATAATAGCCATAATTTTTAGGGACCATGAGAAACA
TGAAGAAGCATTAAAGGAATGGGAAATTATTGAAAAAGCTTACTTGCCCCTAATTTCACTATCAGAACTCTCCTATTTTC
TAATAAAAAACGGCGTGAATCTTGAAGTAGTAAATGAGGTAATAAGCGATCCGAAAATTGAGATAGTCCCAAATACAATA
GAGGACGTTCGTTTTGCGTTAGCTAACAAAGAGAAAATAAAGGGATATGACGATTTTAACGACTTCCTAATACTCTCAAC
AGCTAAAAGGCTCGATCTACCTTTACTTACTTTTGATAAAAAACTGAAAATGAAAAGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8859.19 Da Isoelectric Point: 5.1617
>AT947 WP_009989998.1 NC_002754:1511957-1512196 [Saccharolobus solfataricus P2]
MEEVKVTRNYQITIPYEIRQKLGIKIGDKLIVTVDGDKIVIEKKKGNISSLNLTLGKKITDEEINETINEAGREIADSS
MEEVKVTRNYQITIPYEIRQKLGIKIGDKLIVTVDGDKIVIEKKKGNISSLNLTLGKKITDEEINETINEAGREIADSS
Download Length: 240 bp
>AT947 NC_002754:1511957-1512196 [Saccharolobus solfataricus P2]
ATGGAAGAGGTTAAGGTAACGAGGAATTATCAGATTACCATACCTTATGAAATAAGGCAAAAATTAGGAATAAAAATAGG
TGATAAGCTAATTGTGACAGTTGATGGAGACAAAATAGTTATTGAAAAGAAGAAGGGAAATATATCTTCTCTAAACTTAA
CTTTAGGTAAGAAAATAACTGATGAGGAAATAAATGAGACAATAAATGAGGCTGGAAGAGAAATTGCAGACAGTAGTTGA
ATGGAAGAGGTTAAGGTAACGAGGAATTATCAGATTACCATACCTTATGAAATAAGGCAAAAATTAGGAATAAAAATAGG
TGATAAGCTAATTGTGACAGTTGATGGAGACAAAATAGTTATTGAAAAGAAGAAGGGAAATATATCTTCTCTAAACTTAA
CTTTAGGTAAGAAAATAACTGATGAGGAAATAAATGAGACAATAAATGAGGCTGGAAGAGAAATTGCAGACAGTAGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T956 | Sulfolobus solfataricus P2 |
36.364 |
96.032 |
0.349 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT956 | Sulfolobus solfataricus P2 |
50 |
93.151 |
0.466 |
Multiple sequence alignment
References
(1) Charlotte R Cooper et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society Transactions 37(Pt 1):123-6. [PubMed:19143615]
(2) Sabrina Tachdjian et al. (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of Bacteriology 188(12):4553-9. [PubMed:16740961]