Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1893184..1893380 Replicon chromosome
Accession NZ_CP026615
Organism Clostridioides difficile strain R3

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag C4E42_RS08475 Protein ID WP_003424190.1
Coordinates 1893184..1893336 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1893280..1893380 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E42_RS08445 1888269..1888910 + 642 WP_003424198.1 SdpI family protein -
C4E42_RS08450 1889170..1889501 + 332 Protein_1643 carboxymuconolactone decarboxylase family protein -
C4E42_RS08455 1890033..1890197 + 165 WP_003424195.1 hypothetical protein -
C4E42_RS08460 1890421..1891266 - 846 WP_003424194.1 DUF4878 domain-containing protein -
C4E42_RS19325 1891811..1892356 - 546 WP_077699404.1 site-specific integrase -
C4E42_RS19330 1892422..1892664 - 243 WP_003424191.1 hypothetical protein -
C4E42_RS08475 1893184..1893336 + 153 WP_003424190.1 hypothetical protein Toxin
- 1893280..1893380 - 101 NuclAT_0 - Antitoxin
C4E42_RS08480 1897260..1897448 - 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
C4E42_RS08485 1897636..1897869 + 234 WP_003424184.1 hypothetical protein -
C4E42_RS08490 1897856..1898113 + 258 WP_003424182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1887237..1909410 22173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T95293 WP_003424190.1 NZ_CP026615:1893184-1893336 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

>T95293 NZ_CP026615:1893184-1893336 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT95293 NZ_CP026615:c1893380-1893280 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References