Detailed information of TA system TA095293

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1893184..1893380
• Replicon: chromosome
• Accession: NZ_CP026615
• Organism: Clostridioides difficile strain R3

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: C4E42_RS08475
• Protein ID: WP_003424190.1
• Coordinates: 1893184..1893336 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	1893280..1893380 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4E42_RS08445	1888269..1888910	+	642	WP_003424198.1	SdpI family protein	-
C4E42_RS08450	1889170..1889501	+	332	Protein_1643	carboxymuconolactone decarboxylase family protein	-
C4E42_RS08455	1890033..1890197	+	165	WP_003424195.1	hypothetical protein	-
C4E42_RS08460	1890421..1891266	-	846	WP_003424194.1	DUF4878 domain-containing protein	-
C4E42_RS19325	1891811..1892356	-	546	WP_077699404.1	site-specific integrase	-
C4E42_RS19330	1892422..1892664	-	243	WP_003424191.1	hypothetical protein	-
C4E42_RS08475	1893184..1893336	+	153	WP_003424190.1	hypothetical protein	Toxin
-	1893280..1893380	-	101	NuclAT_0	-	Antitoxin
C4E42_RS08480	1897260..1897448	-	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
C4E42_RS08485	1897636..1897869	+	234	WP_003424184.1	hypothetical protein	-
C4E42_RS08490	1897856..1898113	+	258	WP_003424182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1887237..1909410	22173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T95293 WP_003424190.1 NZ_CP026615:1893184-1893336 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T95293 NZ_CP026615:1893184-1893336 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin

Nucleotide

• Length: 101 bp

>AT95293 NZ_CP026615:c1893380-1893280 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin