95290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2201463..2201659 Replicon chromosome
Accession NZ_CP026614
Organism Clostridioides difficile strain R2

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag C4E26_RS10715 Protein ID WP_003424190.1
Coordinates 2201507..2201659 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 2201463..2201563 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E26_RS10700 2196731..2196988 - 258 WP_003424182.1 hypothetical protein -
C4E26_RS10705 2196975..2197207 - 233 Protein_1967 hypothetical protein -
C4E26_RS10710 2197395..2197583 + 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
- 2201463..2201563 + 101 NuclAT_0 - Antitoxin
C4E26_RS10715 2201507..2201659 - 153 WP_003424190.1 hypothetical protein Toxin
C4E26_RS19335 2202179..2202421 + 243 WP_003424191.1 hypothetical protein -
C4E26_RS19340 2202487..2203032 + 546 WP_077699404.1 site-specific integrase -
C4E26_RS10730 2203577..2204422 + 846 WP_003424194.1 DUF4878 domain-containing protein -
C4E26_RS10735 2204646..2204810 - 165 WP_003424195.1 hypothetical protein -
C4E26_RS10740 2205342..2205673 - 332 Protein_1974 carboxymuconolactone decarboxylase family protein -
C4E26_RS10745 2205933..2206574 - 642 WP_003424198.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / tet(40) - 1942864..2229173 286309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T95290 WP_003424190.1 NZ_CP026614:c2201659-2201507 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

>T95290 NZ_CP026614:c2201659-2201507 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT95290 NZ_CP026614:2201463-2201563 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References