Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2201461..2201657 Replicon chromosome
Accession NZ_CP026613
Organism Clostridioides difficile strain R1

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag C4E25_RS10715 Protein ID WP_003424190.1
Coordinates 2201505..2201657 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 2201461..2201561 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E25_RS10700 2196728..2196985 - 258 WP_003424182.1 hypothetical protein -
C4E25_RS10705 2196972..2197205 - 234 WP_003424184.1 hypothetical protein -
C4E25_RS10710 2197393..2197581 + 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
- 2201461..2201561 + 101 NuclAT_0 - Antitoxin
C4E25_RS10715 2201505..2201657 - 153 WP_003424190.1 hypothetical protein Toxin
C4E25_RS19330 2202177..2202419 + 243 WP_003424191.1 hypothetical protein -
C4E25_RS19335 2202485..2203030 + 546 WP_077699404.1 site-specific integrase -
C4E25_RS10730 2203575..2204420 + 846 WP_003424194.1 DUF4878 domain-containing protein -
C4E25_RS10735 2204644..2204808 - 165 WP_003424195.1 hypothetical protein -
C4E25_RS10740 2205340..2205671 - 332 Protein_1974 carboxymuconolactone decarboxylase family protein -
C4E25_RS10745 2205931..2206572 - 642 WP_003424198.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / tet(40) - 1942861..2229171 286310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T95287 WP_003424190.1 NZ_CP026613:c2201657-2201505 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

>T95287 NZ_CP026613:c2201657-2201505 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT95287 NZ_CP026613:2201461-2201561 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References