Detailed information of TA system TA089616

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3617302..3617522
• Replicon: chromosome
• Accession: NZ_CP025046
• Organism: Clostridioides difficile strain W0022a

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: CWR55_RS19875
• Protein ID: WP_009901465.1
• Coordinates: 3617361..3617522 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	3617302..3617441 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWR55_RS16685	3612438..3614780	-	2343	WP_100852723.1	tape measure protein	-
CWR55_RS16690	3614850..3615620	-	771	WP_021434741.1	SHOCT domain-containing protein	-
CWR55_RS16695	3615899..3616720	-	822	WP_050579201.1	hypothetical protein	-
CWR55_RS16700	3616847..3617017	-	171	WP_021361718.1	ribbon-helix-helix domain-containing protein	-
-	3617302..3617441	+	140	NuclAT_7	-	Antitoxin
-	3617302..3617441	+	140	NuclAT_8	-	Antitoxin
CWR55_RS19875	3617361..3617522	-	162	WP_009901465.1	hypothetical protein	Toxin
CWR55_RS16710	3617843..3618283	-	441	WP_021360957.1	phage XkdN-like family protein	-
CWR55_RS16715	3618288..3618545	-	258	WP_015984846.1	hypothetical protein	-
CWR55_RS16720	3618598..3619068	-	471	WP_015984845.1	phage tail tube protein	-
CWR55_RS16725	3619090..3620400	-	1311	WP_074108958.1	phage tail sheath family protein	-
CWR55_RS16730	3620401..3620577	-	177	WP_021416562.1	hypothetical protein	-
CWR55_RS16735	3620570..3621007	-	438	WP_042741663.1	hypothetical protein	-
CWR55_RS16740	3621000..3621425	-	426	WP_009896626.1	HK97 gp10 family phage protein	-
CWR55_RS16745	3621425..3621787	-	363	WP_021379430.1	hypothetical protein	-
CWR55_RS16750	3621787..3622131	-	345	WP_021371051.1	phage head-tail connector protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3595881..3650048	54167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T89616 WP_009901465.1 NZ_CP025046:c3617522-3617361 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T89616 NZ_CP025046:c3617522-3617361 [Clostridioides difficile]
ATGGACAATTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGTTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT89616 NZ_CP025046:3617302-3617441 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin