Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2662198..2662407 Replicon chromosome
Accession NZ_CP025046
Organism Clostridioides difficile strain W0022a

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CWR55_RS12655 Protein ID WP_004454815.1
Coordinates 2662249..2662407 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2662198..2662332 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR55_RS12640 2657825..2659453 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CWR55_RS12645 2659574..2660569 + 996 WP_003431031.1 asparaginase -
CWR55_RS12650 2660758..2661141 - 384 Protein_2400 BlaI/MecI/CopY family transcriptional regulator -
- 2662198..2662332 + 135 NuclAT_4 - Antitoxin
CWR55_RS12655 2662249..2662407 - 159 WP_004454815.1 hypothetical protein Toxin
CWR55_RS12660 2662766..2664136 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
CWR55_RS12665 2664419..2664517 + 99 Protein_2403 Arm DNA-binding domain-containing protein -
CWR55_RS12670 2664536..2664957 + 422 Protein_2404 hypothetical protein -
CWR55_RS12675 2665188..2665460 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
CWR55_RS12680 2665778..2666446 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T89609 WP_004454815.1 NZ_CP025046:c2662407-2662249 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T89609 NZ_CP025046:c2662407-2662249 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT89609 NZ_CP025046:2662198-2662332 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References