Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2701823..2702032 Replicon chromosome
Accession NZ_CP025045
Organism Clostridioides difficile strain W0023a

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CWR56_RS12720 Protein ID WP_004454815.1
Coordinates 2701874..2702032 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2701823..2701957 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR56_RS12705 2697260..2698888 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CWR56_RS12710 2699009..2700004 + 996 WP_003431031.1 asparaginase -
CWR56_RS12715 2700182..2700565 - 384 Protein_2410 BlaI/MecI/CopY family transcriptional regulator -
- 2701823..2701957 + 135 NuclAT_0 - Antitoxin
CWR56_RS12720 2701874..2702032 - 159 WP_004454815.1 hypothetical protein Toxin
CWR56_RS12725 2702326..2703696 - 1371 WP_021373596.1 cell wall-binding protein Cwp29 -
CWR56_RS12730 2703912..2705029 + 1118 Protein_2413 site-specific integrase -
CWR56_RS12735 2705392..2705472 - 81 Protein_2414 VOC family protein -
CWR56_RS12740 2705512..2706180 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T89599 WP_004454815.1 NZ_CP025045:c2702032-2701874 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T89599 NZ_CP025045:c2702032-2701874 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT89599 NZ_CP025045:2701823-2701957 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References