Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1216769..1216974 Replicon chromosome
Accession NZ_CP025045
Organism Clostridioides difficile strain W0023a

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag CWR56_RS05645 Protein ID WP_009896140.1
Coordinates 1216769..1216921 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1216901..1216974 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR56_RS05625 1212231..1212515 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
CWR56_RS05630 1212538..1214055 - 1518 WP_003438169.1 recombinase family protein -
CWR56_RS05635 1214180..1215001 - 822 WP_003438170.1 tetratricopeptide repeat protein -
CWR56_RS05640 1215192..1216619 + 1428 WP_003438171.1 cell wall-binding protein Cwp26 -
CWR56_RS05645 1216769..1216921 + 153 WP_009896140.1 hypothetical protein Toxin
- 1216901..1216974 - 74 NuclAT_3 - Antitoxin
CWR56_RS05650 1218220..1218444 - 225 WP_003438172.1 helix-turn-helix domain-containing protein -
CWR56_RS05655 1219155..1219310 + 156 WP_003438173.1 hypothetical protein -
CWR56_RS05665 1219556..1219807 + 252 WP_003419270.1 hypothetical protein -
CWR56_RS05680 1221017..1221400 - 384 WP_003433385.1 hypothetical protein -
CWR56_RS05685 1221527..1221871 + 345 WP_003433383.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T89593 WP_009896140.1 NZ_CP025045:1216769-1216921 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T89593 NZ_CP025045:1216769-1216921 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT89593 NZ_CP025045:c1216974-1216901 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References