Detailed information of TA system TA081646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 44098..44826
• Replicon: plasmid pEP48
• Accession: NZ_CP023568
• Organism: Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CPI84_RS19520
• Protein ID: WP_041473956.1
• Coordinates: 44512..44826 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CPI84_RS19515
• Protein ID: WP_011113999.1
• Coordinates: 44098..44511 (-)
• Length: 138 a.a.

Genomic Context

Location: 40346..41734 (1389 bp)
Type: Others
Protein ID: WP_041473957.1

Location: 39348..40205 (858 bp)
Type: Others
Protein ID: WP_012814642.1

Location: 42034..43590 (1557 bp)
Type: Others
Protein ID: WP_041473953.1

Location: 44098..44511 (414 bp)
Type: Antitoxin
Protein ID: WP_011113999.1

Location: 44512..44826 (315 bp)
Type: Toxin
Protein ID: WP_041473956.1

Location: 45090..45374 (285 bp)
Type: Others
Protein ID: WP_011078079.1

Location: 45534..45821 (288 bp)
Type: Others
Protein ID: WP_011078058.1

Location: 45811..46065 (255 bp)
Type: Others
Protein ID: WP_011078059.1

Location: 46276..47241 (966 bp)
Type: Others
Protein ID: WP_011078060.1

Location: 47257..48014 (758 bp)
Type: Others
Protein ID: Protein_48

Location: 48213..48454 (242 bp)
Type: Others
Protein ID: Protein_49

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPI84_RS19500	39348..40205	-	858	WP_012814642.1	LysR family transcriptional regulator	-
CPI84_RS19505	40346..41734	+	1389	WP_041473957.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
CPI84_RS19510	42034..43590	-	1557	WP_041473953.1	MCP four helix bundle domain-containing protein	-
CPI84_RS19515	44098..44511	-	414	WP_011113999.1	helix-turn-helix domain-containing protein	Antitoxin
CPI84_RS19520	44512..44826	-	315	WP_041473956.1	type II toxin-antitoxin system HigB family toxin	Toxin
CPI84_RS19525	45090..45374	-	285	WP_011078079.1	VF530 family protein	-
CPI84_RS19530	45534..45821	-	288	WP_011078058.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CPI84_RS19535	45811..46065	-	255	WP_011078059.1	plasmid stabilization protein	-
CPI84_RS19540	46276..47241	-	966	WP_011078060.1	ThiF family adenylyltransferase	-
CPI84_RS19545	47257..48014	-	758	Protein_48	thiazole synthase	-
CPI84_RS19555	48213..48454	-	242	Protein_49	FAD-dependent oxidoreductase	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004445 Erwinia pyrifoliae Ep1/96 Non-Mobilizable plasmid TA006130 1..35904 0.004	inside	Non-Mobilizable plasmid	-	pla / pla	1..48456	48456

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (83-134)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12227.32 Da
• Isoelectric Point: 10.2275

>T81646 WP_041473956.1 NZ_CP023568:c44826-44512 [Erwinia pyrifoliae]
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPEALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK

Nucleotide

• Length: 315 bp

>T81646 NZ_CP023568:c44826-44512 [Erwinia pyrifoliae]
ATGCACTTGATAAGCCGTAGCATGATTAAGGATGCCACTGATAAGTACCCGCAGCATTCCAGGGAACTCCTGGCTCTGAT
GATCGCTATTGAAAAAGGGTACTTTAAGGCTCCCGAAGCGTTAAAGGCGGCGTTTCCATCACTGGACAATCTGAAATATT
TAGATAAGCACTACGTTATCAATATTGGCCGCAATGACTTGCGTTTAGTTGCGCTGGTATTTTTTGAGTCTCAAAAATTT
TATGTAAGACATGTGTTTACCCACAAAGAGTACGACGTATTTACAGCGTTACATCGCACAAAGGGGAAAAAATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14905.32 Da
• Isoelectric Point: 4.6233

>AT81646 WP_011113999.1 NZ_CP023568:c44511-44098 [Erwinia pyrifoliae]
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID

Nucleotide

• Length: 414 bp

>AT81646 NZ_CP023568:c44511-44098 [Erwinia pyrifoliae]
ATGCTCGTAGCCGACATCATCAAAGCCGGAGAGGCTTTAACCGCCGTTGCCCCTTTCCTTGCGGGTATTACTGACAAACG
GCAACATGCAGAGGCGCTGGAATTTGTGGAGCACCTTTTACTTAACGACCCGGAAAACCCACTTTTAGATCTGGTTTGTG
CCAAAATCACGGCTTACGAAGACACAGCGCCCGAATTCGCAGAATTTAATGCACAGCTGGCAGCCATGCCGGCAGGCGTT
GCTATGATCCGTTTGCTGCTCGATCAGCACGATTTAACGTTATCCGATTTACCCGAAATCGGTAGCAAATCGATGGTTTC
CCGCGTACTCAATGGCGAGCGTAAACTGACCCTGGAACATGCCAAAAAGTTAGCAACGCGGTTTGCCATATCTCCGGCGT
TGTTCATCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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Source	ID	Structure
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Antitoxin

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Source	ID	Structure
No matching records found