81646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 44098..44826 Replicon plasmid pEP48
Accession NZ_CP023568
Organism Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CPI84_RS19520 Protein ID WP_041473956.1
Coordinates 44512..44826 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CPI84_RS19515 Protein ID WP_011113999.1
Coordinates 44098..44511 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPI84_RS19500 39348..40205 - 858 WP_012814642.1 LysR family transcriptional regulator -
CPI84_RS19505 40346..41734 + 1389 WP_041473957.1 NAD-dependent succinate-semialdehyde dehydrogenase -
CPI84_RS19510 42034..43590 - 1557 WP_041473953.1 MCP four helix bundle domain-containing protein -
CPI84_RS19515 44098..44511 - 414 WP_011113999.1 helix-turn-helix domain-containing protein Antitoxin
CPI84_RS19520 44512..44826 - 315 WP_041473956.1 type II toxin-antitoxin system HigB family toxin Toxin
CPI84_RS19525 45090..45374 - 285 WP_011078079.1 VF530 family protein -
CPI84_RS19530 45534..45821 - 288 WP_011078058.1 type II toxin-antitoxin system RelE/ParE family toxin -
CPI84_RS19535 45811..46065 - 255 WP_011078059.1 plasmid stabilization protein -
CPI84_RS19540 46276..47241 - 966 WP_011078060.1 ThiF family adenylyltransferase -
CPI84_RS19545 47257..48014 - 758 Protein_48 thiazole synthase -
CPI84_RS19555 48213..48454 - 242 Protein_49 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - pla / pla 1..48456 48456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12227.32 Da        Isoelectric Point: 10.2275

>T81646 WP_041473956.1 NZ_CP023568:c44826-44512 [Erwinia pyrifoliae]
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPEALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK

Download         Length: 315 bp

>T81646 NZ_CP023568:c44826-44512 [Erwinia pyrifoliae]
ATGCACTTGATAAGCCGTAGCATGATTAAGGATGCCACTGATAAGTACCCGCAGCATTCCAGGGAACTCCTGGCTCTGAT
GATCGCTATTGAAAAAGGGTACTTTAAGGCTCCCGAAGCGTTAAAGGCGGCGTTTCCATCACTGGACAATCTGAAATATT
TAGATAAGCACTACGTTATCAATATTGGCCGCAATGACTTGCGTTTAGTTGCGCTGGTATTTTTTGAGTCTCAAAAATTT
TATGTAAGACATGTGTTTACCCACAAAGAGTACGACGTATTTACAGCGTTACATCGCACAAAGGGGAAAAAATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14905.32 Da        Isoelectric Point: 4.6233

>AT81646 WP_011113999.1 NZ_CP023568:c44511-44098 [Erwinia pyrifoliae]
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID

Download         Length: 414 bp

>AT81646 NZ_CP023568:c44511-44098 [Erwinia pyrifoliae]
ATGCTCGTAGCCGACATCATCAAAGCCGGAGAGGCTTTAACCGCCGTTGCCCCTTTCCTTGCGGGTATTACTGACAAACG
GCAACATGCAGAGGCGCTGGAATTTGTGGAGCACCTTTTACTTAACGACCCGGAAAACCCACTTTTAGATCTGGTTTGTG
CCAAAATCACGGCTTACGAAGACACAGCGCCCGAATTCGCAGAATTTAATGCACAGCTGGCAGCCATGCCGGCAGGCGTT
GCTATGATCCGTTTGCTGCTCGATCAGCACGATTTAACGTTATCCGATTTACCCGAAATCGGTAGCAAATCGATGGTTTC
CCGCGTACTCAATGGCGAGCGTAAACTGACCCTGGAACATGCCAAAAAGTTAGCAACGCGGTTTGCCATATCTCCGGCGT
TGTTCATCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References