Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 9421..10149 Replicon plasmid pEP48
Accession NZ_CP023568
Organism Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CPI84_RS19335 Protein ID WP_041473956.1
Coordinates 9835..10149 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CPI84_RS19330 Protein ID WP_011113999.1
Coordinates 9421..9834 (-) Length 138 a.a.

Genomic Context

CPI84_RS19320CPI84_RS19315CPI84_RS19325CPI84_RS19330CPI84_RS19335CPI84_RS19340CPI84_RS19345CPI84_RS19350CPI84_RS19355CPI84_RS19360CPI84_RS19365CPI84_RS19370CPI84_RS19375
Location: 5669..7057 (1389 bp)
Type: Others
Protein ID: WP_041473957.1
Location: 4671..5528 (858 bp)
Type: Others
Protein ID: WP_012814642.1
Location: 7357..8913 (1557 bp)
Type: Others
Protein ID: WP_041473953.1
Location: 9421..9834 (414 bp)
Type: Antitoxin
Protein ID: WP_011113999.1
Location: 9835..10149 (315 bp)
Type: Toxin
Protein ID: WP_041473956.1
Location: 10413..10697 (285 bp)
Type: Others
Protein ID: WP_011078079.1
Location: 10857..11144 (288 bp)
Type: Others
Protein ID: WP_011078058.1
Location: 11134..11388 (255 bp)
Type: Others
Protein ID: WP_011078059.1
Location: 11599..12564 (966 bp)
Type: Others
Protein ID: WP_011078060.1
Location: 12580..13338 (759 bp)
Type: Others
Protein ID: WP_012814638.1
Location: 13342..13539 (198 bp)
Type: Others
Protein ID: WP_012814637.1
Location: 13536..14468 (933 bp)
Type: Others
Protein ID: WP_041473952.1
Location: 14844..15035 (192 bp)
Type: Others
Protein ID: Protein_15
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPI84_RS193154671..5528-858WP_012814642.1LysR family transcriptional regulator-
CPI84_RS193205669..7057+1389WP_041473957.1NAD-dependent succinate-semialdehyde dehydrogenase-
CPI84_RS193257357..8913-1557WP_041473953.1MCP four helix bundle domain-containing protein-
CPI84_RS193309421..9834-414WP_011113999.1helix-turn-helix domain-containing proteinAntitoxin
CPI84_RS193359835..10149-315WP_041473956.1type II toxin-antitoxin system HigB family toxinToxin
CPI84_RS1934010413..10697-285WP_011078079.1VF530 family protein-
CPI84_RS1934510857..11144-288WP_011078058.1type II toxin-antitoxin system RelE/ParE family toxin-
CPI84_RS1935011134..11388-255WP_011078059.1plasmid stabilization protein-
CPI84_RS1935511599..12564-966WP_011078060.1ThiF family adenylyltransferase-
CPI84_RS1936012580..13338-759WP_012814638.1thiazole synthase-
CPI84_RS1936513342..13539-198WP_012814637.1sulfur carrier protein ThiS-
CPI84_RS1937013536..14468-933WP_041473952.1FAD-dependent oxidoreductase-
CPI84_RS1937514844..15035-192Protein_15Txe/YoeB family addiction module toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmid-pla / pla1..4845648456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12227.32 Da        Isoelectric Point: 10.2275

>T81644 WP_041473956.1 NZ_CP023568:c10149-9835 [Erwinia pyrifoliae]
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPEALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK

Download         Length: 315 bp

>T81644 NZ_CP023568:c10149-9835 [Erwinia pyrifoliae]
ATGCACTTGATAAGCCGTAGCATGATTAAGGATGCCACTGATAAGTACCCGCAGCATTCCAGGGAACTCCTGGCTCTGAT
GATCGCTATTGAAAAAGGGTACTTTAAGGCTCCCGAAGCGTTAAAGGCGGCGTTTCCATCACTGGACAATCTGAAATATT
TAGATAAGCACTACGTTATCAATATTGGCCGCAATGACTTGCGTTTAGTTGCGCTGGTATTTTTTGAGTCTCAAAAATTT
TATGTAAGACATGTGTTTACCCACAAAGAGTACGACGTATTTACAGCGTTACATCGCACAAAGGGGAAAAAATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14905.32 Da        Isoelectric Point: 4.6233

>AT81644 WP_011113999.1 NZ_CP023568:c9834-9421 [Erwinia pyrifoliae]
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID

Download         Length: 414 bp

>AT81644 NZ_CP023568:c9834-9421 [Erwinia pyrifoliae]
ATGCTCGTAGCCGACATCATCAAAGCCGGAGAGGCTTTAACCGCCGTTGCCCCTTTCCTTGCGGGTATTACTGACAAACG
GCAACATGCAGAGGCGCTGGAATTTGTGGAGCACCTTTTACTTAACGACCCGGAAAACCCACTTTTAGATCTGGTTTGTG
CCAAAATCACGGCTTACGAAGACACAGCGCCCGAATTCGCAGAATTTAATGCACAGCTGGCAGCCATGCCGGCAGGCGTT
GCTATGATCCGTTTGCTGCTCGATCAGCACGATTTAACGTTATCCGATTTACCCGAAATCGGTAGCAAATCGATGGTTTC
CCGCGTACTCAATGGCGAGCGTAAACTGACCCTGGAACATGCCAAAAAGTTAGCAACGCGGTTTGCCATATCTCCGGCGT
TGTTCATCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References