81165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 323285..324076 Replicon chromosome
Accession NZ_CP023390
Organism Staphylococcus aureus subsp. aureus str. Newman strain NYU_Newman

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag CNH35_RS01505 Protein ID WP_000525007.1
Coordinates 323285..323749 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag CNH35_RS01510 Protein ID WP_000333630.1
Coordinates 323762..324076 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNH35_RS01485 318821..320752 + 1932 Protein_279 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
CNH35_RS01490 320846..322051 - 1206 WP_000264186.1 site-specific integrase -
CNH35_RS01495 322162..322341 + 180 WP_000337827.1 hypothetical protein -
CNH35_RS01500 322321..323253 - 933 WP_000392183.1 hypothetical protein -
CNH35_RS01505 323285..323749 - 465 WP_000525007.1 hypothetical protein Toxin
CNH35_RS01510 323762..324076 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
CNH35_RS01515 324228..324464 + 237 WP_001121116.1 helix-turn-helix domain-containing protein -
CNH35_RS01520 324478..324657 + 180 WP_000438352.1 hypothetical protein -
CNH35_RS01525 324758..325240 - 483 WP_000394410.1 hypothetical protein -
CNH35_RS01530 325300..326049 + 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
CNH35_RS01535 326065..326283 + 219 WP_000993180.1 hypothetical protein -
CNH35_RS01540 326313..326576 + 264 WP_001124198.1 helix-turn-helix domain-containing protein -
CNH35_RS01545 326588..326749 + 162 WP_000066021.1 DUF1270 family protein -
CNH35_RS01550 326841..327101 + 261 WP_000291089.1 DUF1108 family protein -
CNH35_RS01555 327111..327332 + 222 WP_000815401.1 DUF2483 family protein -
CNH35_RS01560 327325..328113 + 789 WP_000134097.1 ATP-binding protein -
CNH35_RS01565 328142..328693 + 552 WP_000704705.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - geh 316295..363190 46895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T81165 WP_000525007.1 NZ_CP023390:c323749-323285 [Staphylococcus aureus subsp. aureus str. Newman]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T81165 NZ_CP023390:c323749-323285 [Staphylococcus aureus subsp. aureus str. Newman]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT81165 WP_000333630.1 NZ_CP023390:c324076-323762 [Staphylococcus aureus subsp. aureus str. Newman]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT81165 NZ_CP023390:c324076-323762 [Staphylococcus aureus subsp. aureus str. Newman]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATTTA
GAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References