Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1184619..1184799 Replicon chromosome
Accession NZ_CP022905
Organism Staphylococcus aureus strain 628

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag CGQ03_RS06375 Protein ID WP_001801861.1
Coordinates 1184704..1184799 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1184619..1184676 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ03_RS06345 1180328..1180462 + 135 WP_001791797.1 hypothetical protein -
CGQ03_RS06350 1180626..1182182 + 1557 WP_000028669.1 type I restriction-modification system subunit M -
CGQ03_RS06355 1182175..1183404 + 1230 WP_000072627.1 restriction endonuclease subunit S -
CGQ03_RS06360 1183856..1184350 + 495 Protein_1141 transposase -
CGQ03_RS06365 1184341..1184502 + 162 Protein_1142 transposase -
CGQ03_RS06370 1184480..1184581 - 102 WP_001792025.1 hypothetical protein -
- 1184619..1184676 + 58 - - Antitoxin
CGQ03_RS06375 1184704..1184799 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
CGQ03_RS06380 1184944..1185956 + 1013 Protein_1145 IS3 family transposase -
CGQ03_RS06385 1186154..1186726 - 573 WP_000414216.1 hypothetical protein -
CGQ03_RS06390 1186827..1187168 - 342 WP_000627540.1 DUF3969 family protein -
CGQ03_RS06395 1187209..1187835 - 627 WP_000669024.1 hypothetical protein -
CGQ03_RS06400 1187910..1188905 - 996 WP_000070642.1 DUF4352 domain-containing protein -
CGQ03_RS06405 1188986..1189636 - 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - selk / hlgA / lukD 1155122..1189600 34478


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-48)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T80063 WP_001801861.1 NZ_CP022905:c1184799-1184704 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T80063 NZ_CP022905:c1184799-1184704 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT80063 NZ_CP022905:1184619-1184676 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References