Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 4843806..4844177 Replicon chromosome
Accession NZ_CP022689
Organism Escherichia coli strain CDC#03-98

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag RM34_RS25955 Protein ID WP_001443846.1
Coordinates 4844028..4844177 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 4843806..4843984 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RM34_RS25925 4839558..4839728 + 171 WP_001625136.1 hypothetical protein -
RM34_RS25930 4839761..4841134 + 1374 WP_000123746.1 ATP-dependent RNA helicase DbpA -
RM34_RS25935 4841263..4842198 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
RM34_RS25940 4842250..4843485 - 1236 WP_000040839.1 site-specific integrase -
RM34_RS25945 4843487..4843702 - 216 WP_000079604.1 excisionase XisR -
RM34_RS25950 4843802..4843990 - 189 WP_001302840.1 DUF1187 family protein -
- 4843806..4843984 + 179 NuclAT_0 - Antitoxin
- 4843806..4843984 + 179 NuclAT_0 - Antitoxin
- 4843806..4843984 + 179 NuclAT_0 - Antitoxin
- 4843806..4843984 + 179 NuclAT_0 - Antitoxin
RM34_RS25955 4844028..4844177 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
RM34_RS25960 4844233..4845042 - 810 WP_000166313.1 recombination protein RecT -
RM34_RS25965 4845035..4847635 - 2601 WP_000105140.1 exodeoxyribonuclease VIII -
RM34_RS25970 4847737..4848012 - 276 WP_001344816.1 hypothetical protein -
RM34_RS25975 4848087..4848257 - 171 WP_001352098.1 conserved protein, Rac prophage -
RM34_RS25980 4848257..4848478 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4842250..4891403 49153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T79580 WP_001443846.1 NZ_CP022689:c4844177-4844028 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

>T79580 NZ_CP022689:c4844177-4844028 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin


Download         Length: 179 bp

>AT79580 NZ_CP022689:4843806-4843984 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References