Detailed information of TA system TA079160

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2526196..2526398
• Replicon: chromosome
• Accession: NZ_CP022524
• Organism: Clostridioides difficile strain DH/NAP11/106/ST-42

Toxin (Protein)

• Gene name: CD2299.1
• Uniprot ID: Q185H1
• Locus tag: CGC51_RS11910
• Protein ID: WP_004454589.1
• Coordinates: 2526246..2526398 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ1641
Locus tag	-
Coordinates	2526196..2526325 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGC51_RS11880	2521500..2521964	+	465	WP_004454576.1	hypothetical protein	-
CGC51_RS11890	2522293..2522454	-	162	WP_004454578.1	hypothetical protein	-
CGC51_RS18930	2522506..2523319	-	814	Protein_2215	toxin Bro	-
CGC51_RS18935	2523440..2523592	-	153	WP_009897477.1	hypothetical protein	-
CGC51_RS11905	2525129..2526052	-	924	WP_004454587.1	SHOCT domain-containing protein	-
-	2526196..2526325	+	130	NuclAT_1	-	Antitoxin
CGC51_RS11910	2526246..2526398	-	153	WP_004454589.1	hypothetical protein	Toxin
CGC51_RS11915	2526672..2526995	-	324	WP_009897482.1	hypothetical protein	-
CGC51_RS11920	2527031..2527285	-	255	WP_004454592.1	hypothetical protein	-
CGC51_RS11925	2527717..2528235	-	519	Protein_2221	transposase	-
CGC51_RS18830	2528525..2528899	-	375	Protein_2222	BlaI/MecI/CopY family transcriptional regulator	-
CGC51_RS11935	2529004..2529378	-	375	WP_004454597.1	BlaI/MecI/CopY family transcriptional regulator	-
CGC51_RS11940	2530184..2530672	+	489	WP_004454599.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
CGC51_RS18835	2531061..2531231	+	171	WP_004454601.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5817.92 Da
• Isoelectric Point: 10.6365

>T79160 WP_004454589.1 NZ_CP022524:c2526398-2526246 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Nucleotide

• Length: 153 bp

>T79160 NZ_CP022524:c2526398-2526246 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin

Nucleotide

• Length: 130 bp

>AT79160 NZ_CP022524:2526196-2526325 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Structures

Toxin

• AlphaFold DB: A0A125V725

Antitoxin