Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1306766..1306971 Replicon chromosome
Accession NZ_CP022524
Organism Clostridioides difficile strain DH/NAP11/106/ST-42

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag CGC51_RS06200 Protein ID WP_009896140.1
Coordinates 1306766..1306918 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1306898..1306971 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGC51_RS06180 1302228..1302512 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
CGC51_RS06185 1302535..1304052 - 1518 WP_003438169.1 recombinase family protein -
CGC51_RS06190 1304177..1304998 - 822 WP_003438170.1 tetratricopeptide repeat protein -
CGC51_RS06195 1305189..1306616 + 1428 WP_003438171.1 cell wall-binding protein Cwp26 -
CGC51_RS06200 1306766..1306918 + 153 WP_009896140.1 hypothetical protein Toxin
- 1306898..1306971 - 74 NuclAT_3 - Antitoxin
CGC51_RS06205 1308217..1308441 - 225 WP_003438172.1 helix-turn-helix domain-containing protein -
CGC51_RS06210 1309152..1309307 + 156 WP_003438173.1 hypothetical protein -
CGC51_RS06215 1309553..1309804 + 252 WP_003419270.1 hypothetical protein -
CGC51_RS06230 1311014..1311397 - 384 WP_003433385.1 hypothetical protein -
CGC51_RS06235 1311524..1311868 + 345 WP_003433383.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T79157 WP_009896140.1 NZ_CP022524:1306766-1306918 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T79157 NZ_CP022524:1306766-1306918 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT79157 NZ_CP022524:c1306971-1306898 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References