Detailed information of TA system TA079157

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1306766..1306971
• Replicon: chromosome
• Accession: NZ_CP022524
• Organism: Clostridioides difficile strain DH/NAP11/106/ST-42

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: CGC51_RS06200
• Protein ID: WP_009896140.1
• Coordinates: 1306766..1306918 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1306898..1306971 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGC51_RS06180	1302228..1302512	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
CGC51_RS06185	1302535..1304052	-	1518	WP_003438169.1	recombinase family protein	-
CGC51_RS06190	1304177..1304998	-	822	WP_003438170.1	tetratricopeptide repeat protein	-
CGC51_RS06195	1305189..1306616	+	1428	WP_003438171.1	cell wall-binding protein Cwp26	-
CGC51_RS06200	1306766..1306918	+	153	WP_009896140.1	hypothetical protein	Toxin
-	1306898..1306971	-	74	NuclAT_3	-	Antitoxin
CGC51_RS06205	1308217..1308441	-	225	WP_003438172.1	helix-turn-helix domain-containing protein	-
CGC51_RS06210	1309152..1309307	+	156	WP_003438173.1	hypothetical protein	-
CGC51_RS06215	1309553..1309804	+	252	WP_003419270.1	hypothetical protein	-
CGC51_RS06230	1311014..1311397	-	384	WP_003433385.1	hypothetical protein	-
CGC51_RS06235	1311524..1311868	+	345	WP_003433383.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T79157 WP_009896140.1 NZ_CP022524:1306766-1306918 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T79157 NZ_CP022524:1306766-1306918 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT79157 NZ_CP022524:c1306971-1306898 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin