Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 3234608..3234823 | Replicon | chromosome |
| Accession | NZ_CP021447 | ||
| Organism | Clostridioides difficile strain DSM 104451 | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | CDIF104451_RS15010 | Protein ID | WP_011861731.1 |
| Coordinates | 3234680..3234823 (-) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd12 | ||
| Locus tag | - | ||
| Coordinates | 3234608..3234754 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CDIF104451_RS14995 (3230329) | 3230329..3231060 | - | 732 | WP_021423550.1 | UTRA domain-containing protein | - |
| CDIF104451_RS15000 (3231502) | 3231502..3233220 | - | 1719 | WP_021359643.1 | putative 2-aminoethylphosphonate ABC transporter permease subunit | - |
| CDIF104451_RS15005 (3233225) | 3233225..3234070 | - | 846 | WP_236733572.1 | ATP-binding cassette domain-containing protein | - |
| - (3234608) | 3234608..3234754 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3234608) | 3234608..3234754 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3234608) | 3234608..3234754 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3234608) | 3234608..3234758 | + | 151 | NuclAT_2 | - | - |
| CDIF104451_RS15010 (3234680) | 3234680..3234823 | - | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| CDIF104451_RS15015 (3235081) | 3235081..3235269 | + | 189 | WP_009898401.1 | hypothetical protein | - |
| CDIF104451_RS15020 (3235679) | 3235679..3236263 | - | 585 | WP_021369915.1 | hypothetical protein | - |
| CDIF104451_RS15025 (3236266) | 3236266..3236757 | - | 492 | WP_021369914.1 | hypothetical protein | - |
| CDIF104451_RS15030 (3237007) | 3237007..3237804 | - | 798 | WP_021423109.1 | N-acetylmuramoyl-L-alanine amidase | - |
| CDIF104451_RS15035 (3237804) | 3237804..3238061 | - | 258 | WP_021423108.1 | phage holin family protein | - |
| CDIF104451_RS15040 (3238065) | 3238065..3238355 | - | 291 | WP_021363500.1 | hypothetical protein | - |
| CDIF104451_RS15045 (3238386) | 3238386..3238952 | - | 567 | WP_070114877.1 | hypothetical protein | - |
| CDIF104451_RS15050 (3238985) | 3238985..3239167 | - | 183 | WP_070114876.1 | hypothetical protein | - |
| CDIF104451_RS15055 (3239167) | 3239167..3239460 | - | 294 | WP_021401304.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T76662 WP_011861731.1 NZ_CP021447:c3234823-3234680 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T76662 NZ_CP021447:c3234823-3234680 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
Antitoxin
Download Length: 147 bp
>AT76662 NZ_CP021447:3234608-3234754 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
