Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2854169..2854378 Replicon chromosome
Accession NZ_CP021445
Organism Clostridioides difficile strain DSM 104450

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF104450_RS13830 Protein ID WP_004454815.1
Coordinates 2854220..2854378 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2854169..2854303 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF104450_RS13815 (CDIF104450_02781) 2849607..2851235 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF104450_RS13820 (CDIF104450_02782) 2851356..2852351 + 996 WP_003431031.1 asparaginase -
CDIF104450_RS13825 (CDIF104450_02783) 2852529..2852912 - 384 WP_021390236.1 BlaI/MecI/CopY family transcriptional regulator -
- 2854169..2854303 + 135 - - Antitoxin
CDIF104450_RS13830 (CDIF104450_02785) 2854220..2854378 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF104450_RS13835 (CDIF104450_02786) 2854737..2856107 - 1371 WP_021390237.1 cell wall-binding protein Cwp29 -
CDIF104450_RS13840 (CDIF104450_02787) 2856321..2857439 + 1119 WP_021366970.1 site-specific integrase -
CDIF104450_RS13845 (CDIF104450_02788) 2857756..2858424 - 669 WP_021366877.1 VanZ family protein -
CDIF104450_RS13850 2858520..2858651 - 132 WP_021361939.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T76648 WP_004454815.1 NZ_CP021445:c2854378-2854220 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T76648 NZ_CP021445:c2854378-2854220 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT76648 NZ_CP021445:2854169-2854303 [Clostridioides difficile]
AAGAATAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References