Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1545485..1545681 Replicon chromosome
Accession NZ_CP021445
Organism Clostridioides difficile strain DSM 104450

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag CDIF104450_RS07610 Protein ID WP_009902496.1
Coordinates 1545485..1545637 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1545581..1545681 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF104450_RS07590 (CDIF104450_01512) 1541062..1541610 - 549 WP_011861206.1 DUF308 domain-containing protein -
CDIF104450_RS07595 (CDIF104450_01513) 1541762..1542190 + 429 WP_021366451.1 DMT family transporter -
CDIF104450_RS07600 (CDIF104450_01514) 1542257..1542925 + 669 WP_003429358.1 diphthine--ammonia ligase -
CDIF104450_RS07605 (CDIF104450_01515) 1543043..1544398 - 1356 WP_003438549.1 MATE family efflux transporter -
CDIF104450_RS07610 (CDIF104450_01516) 1545485..1545637 + 153 WP_009902496.1 hypothetical protein Toxin
- 1545581..1545681 - 101 - - Antitoxin
CDIF104450_RS07615 (CDIF104450_01517) 1546730..1548463 - 1734 WP_009902497.1 sensor domain-containing diguanylate cyclase -
CDIF104450_RS07620 (CDIF104450_01518) 1548703..1549548 - 846 WP_021366437.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T76637 WP_009902496.1 NZ_CP021445:1545485-1545637 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T76637 NZ_CP021445:1545485-1545637 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGCGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT76637 NZ_CP021445:c1545681-1545581 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCGCTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References