Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1341150..1341355 Replicon chromosome
Accession NZ_CP021445
Organism Clostridioides difficile strain DSM 104450

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag CDIF104450_RS06650 Protein ID WP_009896140.1
Coordinates 1341150..1341302 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1341282..1341355 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF104450_RS06630 (CDIF104450_01320) 1336612..1336896 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
CDIF104450_RS06635 (CDIF104450_01321) 1336919..1338436 - 1518 WP_011861147.1 recombinase family protein -
CDIF104450_RS06640 (CDIF104450_01322) 1338561..1339382 - 822 WP_021390130.1 tetratricopeptide repeat protein -
CDIF104450_RS06645 (CDIF104450_01323) 1339573..1341000 + 1428 WP_021366431.1 cell wall-binding protein Cwp26 -
CDIF104450_RS06650 1341150..1341302 + 153 WP_009896140.1 hypothetical protein Toxin
- 1341282..1341355 - 74 - - Antitoxin
CDIF104450_RS06655 (CDIF104450_01324) 1342669..1342893 - 225 WP_021366542.1 helix-turn-helix transcriptional regulator -
CDIF104450_RS06660 (CDIF104450_01325) 1344005..1344223 + 219 WP_009889000.1 hypothetical protein -
CDIF104450_RS06665 (CDIF104450_01326) 1344520..1344645 + 126 WP_003433391.1 hypothetical protein -
CDIF104450_RS06670 (CDIF104450_01327) 1344868..1345062 + 195 WP_021367700.1 hypothetical protein -
CDIF104450_RS06675 (CDIF104450_01328) 1345431..1345814 - 384 WP_003433385.1 hypothetical protein -
CDIF104450_RS06680 (CDIF104450_01329) 1345941..1346285 + 345 WP_021390131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T76635 WP_009896140.1 NZ_CP021445:1341150-1341302 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T76635 NZ_CP021445:1341150-1341302 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTTAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT76635 NZ_CP021445:c1341355-1341282 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References