Detailed information of TA system TA076631

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1203431..1203646
• Replicon: chromosome
• Accession: NZ_CP021445
• Organism: Clostridioides difficile strain DSM 104450

Toxin (Protein)

• Gene name: CD2889
• Uniprot ID: Q183X5
• Locus tag: CDIF104450_RS05950
• Protein ID: WP_011861731.1
• Coordinates: 1203431..1203574 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1203496..1203646 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF104450_RS05925 (CDIF104450_01179)	1199103..1199450	+	348	WP_009898409.1	hypothetical protein	-
CDIF104450_RS05930 (CDIF104450_01180)	1199616..1200134	+	519	WP_009898407.1	DUF5706 domain-containing protein	-
CDIF104450_RS05935 (CDIF104450_01181)	1200198..1201784	-	1587	WP_015984865.1	hypothetical protein	-
CDIF104450_RS05940 (CDIF104450_01182)	1201760..1202281	-	522	WP_009898403.1	ImmA/IrrE family metallo-endopeptidase	-
CDIF104450_RS05945 (CDIF104450_01183)	1202983..1203171	-	189	WP_009898401.1	hypothetical protein	-
CDIF104450_RS05950	1203431..1203574	+	144	WP_011861731.1	hypothetical protein	Toxin
-	1203496..1203646	-	151	-	-	Antitoxin
CDIF104450_RS05955 (CDIF104450_01184)	1204081..1204458	+	378	WP_021391346.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF104450_RS05960 (CDIF104450_01185)	1204568..1204951	+	384	WP_015984867.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF104450_RS05965 (CDIF104450_01186)	1205145..1205720	+	576	WP_021360401.1	GntR family transcriptional regulator	-
CDIF104450_RS05970 (CDIF104450_01187)	1205746..1206159	+	414	WP_009896035.1	PTS sugar transporter subunit IIA	-
CDIF104450_RS05975 (CDIF104450_01188)	1206163..1206906	+	744	WP_003437997.1	BtpA/SgcQ family protein	-
CDIF104450_RS05980 (CDIF104450_01189)	1206906..1207376	+	471	WP_003428544.1	PTS sugar transporter subunit IIB	-
CDIF104450_RS05985 (CDIF104450_01190)	1207393..1208151	+	759	WP_009888882.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1149304..1216973	67669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5399.34 Da
• Isoelectric Point: 10.8277

>T76631 WP_011861731.1 NZ_CP021445:1203431-1203574 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH

Nucleotide

• Length: 144 bp

>T76631 NZ_CP021445:1203431-1203574 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA

Antitoxin

Nucleotide

• Length: 151 bp

>AT76631 NZ_CP021445:c1203646-1203496 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG

Structures

Toxin

• AlphaFold DB: A0A069A3R1

Antitoxin