Detailed information of TA system TA076627

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1183543..1183763
• Replicon: chromosome
• Accession: NZ_CP021445
• Organism: Clostridioides difficile strain DSM 104450

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: CDIF104450_RS05825
• Protein ID: WP_009901465.1
• Coordinates: 1183543..1183704 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1183624..1183763 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF104450_RS05775 (CDIF104450_01151)	1178655..1178888	+	234	WP_003429842.1	hypothetical protein	-
CDIF104450_RS05780 (CDIF104450_01152)	1178898..1179299	+	402	WP_015984842.1	hypothetical protein	-
CDIF104450_RS05785 (CDIF104450_01153)	1179293..1179640	+	348	WP_015984843.1	hypothetical protein	-
CDIF104450_RS05790 (CDIF104450_01154)	1179640..1180065	+	426	WP_009896626.1	HK97 gp10 family phage protein	-
CDIF104450_RS05795 (CDIF104450_01155)	1180058..1180495	+	438	WP_009901457.1	hypothetical protein	-
CDIF104450_RS05800 (CDIF104450_01156)	1180488..1180664	+	177	WP_021368348.1	hypothetical protein	-
CDIF104450_RS05805 (CDIF104450_01157)	1180665..1181975	+	1311	WP_015984844.1	phage tail sheath family protein	-
CDIF104450_RS05810 (CDIF104450_01158)	1181997..1182467	+	471	WP_015984845.1	phage tail tube protein	-
CDIF104450_RS05815 (CDIF104450_01159)	1182520..1182777	+	258	WP_015984846.1	hypothetical protein	-
CDIF104450_RS05820 (CDIF104450_01160)	1182782..1183222	+	441	WP_015984847.1	hypothetical protein	-
CDIF104450_RS05825	1183543..1183704	+	162	WP_009901465.1	hypothetical protein	Toxin
-	1183624..1183763	-	140	-	-	Antitoxin
CDIF104450_RS05830 (CDIF104450_01161)	1183853..1184086	+	234	WP_015984848.1	hypothetical protein	-
CDIF104450_RS05835 (CDIF104450_01162)	1184146..1184673	+	528	WP_015984849.1	DUF4352 domain-containing protein	-
CDIF104450_RS05840 (CDIF104450_01163)	1184815..1185375	+	561	WP_015984850.1	hypothetical protein	-
CDIF104450_RS05845 (CDIF104450_01164)	1185453..1187741	+	2289	WP_015984851.1	tape measure protein	-
CDIF104450_RS05850 (CDIF104450_01165)	1187758..1188459	+	702	WP_015984852.1	LysM peptidoglycan-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1149304..1216973	67669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T76627 WP_009901465.1 NZ_CP021445:1183543-1183704 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T76627 NZ_CP021445:1183543-1183704 [Clostridioides difficile]
ATGGACAATTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGTTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT76627 NZ_CP021445:c1183763-1183624 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin