Detailed information of TA system TA076440

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2044901..2045097
• Replicon: chromosome
• Accession: NZ_CP021319
• Organism: Clostridioides difficile strain DSM 101085

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: CDIF101085_RS09710
• Protein ID: WP_003424190.1
• Coordinates: 2044945..2045097 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2044901..2045001 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF101085_RS09685	2040909..2041103	-	195	WP_003424168.1	hypothetical protein	-
CDIF101085_RS09690	2041640..2042020	-	381	WP_003424180.1	hypothetical protein	-
CDIF101085_RS09695	2042013..2042270	-	258	WP_003424182.1	hypothetical protein	-
CDIF101085_RS09700	2042257..2042490	-	234	WP_003424184.1	hypothetical protein	-
CDIF101085_RS09705	2042678..2042866	+	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
-	2044901..2045001	+	101	NuclAT_0	-	Antitoxin
CDIF101085_RS09710	2044945..2045097	-	153	WP_003424190.1	hypothetical protein	Toxin
CDIF101085_RS09715	2045617..2045859	+	243	WP_003424191.1	hypothetical protein	-
CDIF101085_RS09720	2045925..2046470	+	546	WP_077699404.1	site-specific integrase	-
CDIF101085_RS09725	2047015..2047860	+	846	WP_003424194.1	DUF4878 domain-containing protein	-
CDIF101085_RS09730	2048084..2048248	-	165	WP_003424195.1	hypothetical protein	-
CDIF101085_RS09735	2048780..2049111	-	332	Protein_1834	carboxymuconolactone decarboxylase family protein	-
CDIF101085_RS09740	2049371..2049687	-	317	Protein_1835	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2030716..2121966	91250

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T76440 WP_003424190.1 NZ_CP021319:c2045097-2044945 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T76440 NZ_CP021319:c2045097-2044945 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin

Nucleotide

• Length: 101 bp

>AT76440 NZ_CP021319:2044901-2045001 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin